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首頁> 外文會議>NATO advanced research workshop on nanomaterials: Environmental risks and benefits; 20080427-30; Faro(PT) >HUMAN HEALTH RISKS OF ENGINEERED NANOMATERIALS: CRITICAL KNOWLEDGE GAPS IN NANOMATERIALS RISK ASSESSMENT
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HUMAN HEALTH RISKS OF ENGINEERED NANOMATERIALS: CRITICAL KNOWLEDGE GAPS IN NANOMATERIALS RISK ASSESSMENT

機(jī)譯：工程化納米材料的人類健康風(fēng)險：納米材料風(fēng)險評估中的關(guān)鍵知識差距

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There are currently hundreds of available consumer products that contain nanoscale materials. Human exposure is, therefore, likely to occur in occupational and environmental settings. Mounting evidence suggests that some nanomaterials exert toxicity in cultured cells or following in vivo exposures, but this is dependent on the physicochemical characteristics of the materials and the dose. This Working Group report summarizes the discussions of an expert scientific panel regarding the gaps in knowledge that impede effective human health risk assessment for nanomaterials, particularly those that are suspended in a gas or liquid and, thus, deposit on skin or in the respiratory tract. In addition to extensive descriptions of material properties, the Group identified as critical research areas: external and internal dose characterization, mechanisms of response, identification of sensitive subpopulations, and the development of screening strategies and technology to support these investigations. Important concepts in defining health risk are reviewed, as are the specific kinds of studies that will quickly reduce the uncertainties in the risk assessment process.
機(jī)譯：當(dāng)前有數(shù)百種包含納米級材料的可用消費(fèi)產(chǎn)品。因此，在職業(yè)和環(huán)境環(huán)境中很可能發(fā)生人體暴露。越來越多的證據(jù)表明，某些納米材料會在培養(yǎng)的細(xì)胞或體內(nèi)暴露后產(chǎn)生毒性，但這取決于材料的物理化學(xué)特性和劑量。該工作組報告總結(jié)了一個專家科學(xué)小組的討論，該討論涉及阻礙有效對納米材料進(jìn)行人類健康風(fēng)險評估的知識方面的空白，尤其是那些懸浮在氣體或液體中并因此沉積在皮膚或呼吸道中的納米材料。除了對物質(zhì)特性的廣泛描述外，專家組還確定了關(guān)鍵的研究領(lǐng)域：外部和內(nèi)部劑量表征，反應(yīng)機(jī)制，敏感亞群的鑒定以及支持這些研究的篩選策略和技術(shù)的發(fā)展。審查了定義健康風(fēng)險的重要概念，以及將快速減少風(fēng)險評估過程中不確定性的特定類型的研究。

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