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首頁> 外文學位 >Fluorescence-enhanced optical imaging on three-dimensional phantoms using a hand-held probe based frequency-domain intensified charge coupled device (ICCD) optical imager.
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Fluorescence-enhanced optical imaging on three-dimensional phantoms using a hand-held probe based frequency-domain intensified charge coupled device (ICCD) optical imager.

機譯：使用基于手持式探頭的頻域增強電荷耦合器件（ICCD）光學成像儀對三維體模進行熒光增強的光學成像。

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摘要

Fluorescence-enhanced optical imaging is an emerging non-invasive and non-ionizing modality towards breast cancer diagnosis. Various optical imaging systems are currently available, although most of them are limited by bulky instrumentation, or their inability to flexibly image different tissue volumes and shapes. Hand-held based optical imaging systems are a recent development for its improved portability, but are currently limited only to surface mapping.;Herein, a novel optical imager, consisting primarily of a hand-held probe and a gain-modulated intensified charge coupled device (ICCD) detector, is developed towards both surface and tomographic breast imaging. The unique features of this hand-held probe based optical imager are its ability to; (i) image large tissue areas (5×10 sq. cm) in a single scan, (ii) reduce overall imaging time using a unique measurement geometry, and (iii) perform tomographic imaging for tumor three-dimensional (3-D) localization.;Frequency-domain based experimental phantom studies have been performed on slab geometries (650 ml) under different target depths (1-2.5 cm), target volumes (0.45, 0.23 and 0.10 cc), fluorescence absorption contrast ratios (1:0, 1000:1 to 5:1), and number of targets (up to 3), using Indocyanine Green (ICG) as fluorescence contrast agents. An approximate extended Kalman filter based inverse algorithm has been adapted towards 3-D tomographic reconstructions.;Single fluorescence target(s) was reconstructed when located: (i) up to 2.5 cm deep (at 1:0 contrast ratio) and 1.5 cm deep (up to 10:1 contrast ratio) for 0.45 cc-target; and (ii) 1.5 cm deep for target as small as 0.10 cc at 1:0 contrast ratio. In the case of multiple targets, two targets as close as 0.7 cm were tomographically resolved when located 1.5 cm deep. It was observed that performing multi-projection (here dual) based tomographic imaging using a priori target information from surface images, improved the target depth recovery over using single projection based imaging. From a total of 98 experimental phantom studies, the sensitivity and specificity of the imager was estimated as 81-86% and 43-50%, respectively. With 3-D tomographic imaging successfully demonstrated for the first time using a hand-held based optical imager, the clinical translation of this technology is promising upon further experimental validation from in-vitro and in-vivo studies.
機譯：熒光增強光學成像是一種用于乳腺癌診斷的新興非侵入性和非電離形式。當前有各種光學成像系統(tǒng)，盡管它們中的大多數(shù)受到笨重的儀器的限制，或者它們無法靈活地成像不同的組織體積和形狀?；谑殖质降墓鈱W成像系統(tǒng)是其改進的便攜性的最新發(fā)展，但目前僅限于表面映射。這里，一種新穎的光學成像器，主要由手持式探頭和增益調(diào)制的增強電荷耦合器件組成（ICCD）檢測器是針對乳腺表面成像和斷層成像而開發(fā)的。這種基于手持式探頭的光學成像儀的獨特功能是： （i）在單次掃描中對大組織區(qū)域（5×10 sq。cm）進行成像，（ii）使用獨特的測量幾何形狀減少總體成像時間，并且（iii）對腫瘤三維（3-D）進行斷層成像在不同目標深度（1-2.5 cm），目標體積（0.45、0.23和0.10 cc），熒光吸收對比比（1：0）下對平板幾何形狀（650 ml）進行了基于頻域的實驗幻像研究，1000：1至5：1）和目標數(shù)量（最多3個），使用吲哚菁綠（ICG）作為熒光造影劑?；诮茢U展卡爾曼濾波器的逆算法已適用于3-D斷層成像重建;;位于以下位置時重建了單個熒光目標：（i）高達2.5厘米深（以1：0的對比度）和1.5厘米深（最高10：1的對比度）適用于0.45 cc目標； （ii）對比度為1：0時目標小至0.10 cc的目標物深1.5厘米。在有多個目標的情況下，位于1.5厘米深處時，兩個X射線成像目標（0.7厘米左右）被層析成像分辨。已經(jīng)觀察到，使用來自表面圖像的先驗目標信息來執(zhí)行基于多投影（此處為雙重）的斷層成像，與使用基于單投影的成像相比，可以改善目標深度的恢復。從總共98個實驗體模研究中，成像儀的靈敏度和特異性分別估計為81-86％和43-50％。借助基于手持式光學成像儀的3D層析成像首次成功演示，這項技術的臨床翻譯有望在體外和體內(nèi)研究中得到進一步的實驗驗證。

著錄項

  • 作者

    Ge, Jiajia.;

  • 作者單位

    Florida International University.;

  • 授予單位 Florida International University.;
  • 學科 Engineering Biomedical.
  • 學位 Ph.D.
  • 年度 2008
  • 頁碼 242 p.
  • 總頁數(shù) 242
  • 原文格式 PDF
  • 正文語種 eng
  • 中圖分類
  • 關鍵詞

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