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首頁(yè)> 外文學(xué)位 >Interaction of stilbene compounds with the estrogen receptor.
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Interaction of stilbene compounds with the estrogen receptor.

機(jī)譯：二苯乙烯化合物與雌激素受體的相互作用。

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摘要

Stilbene-related pharmaceuticals and personal care products have been detected in sewage effluents and surface waters. The effects of a suite of stilbene-related personal care products and pharmaceutical products were tested in vitro on the human estrogen receptor and rainbow trout estrogen receptor and in vivo in rainbow trout using the vitellogenin biomarker test. The results indicated that many of these compounds behaved similar to known pharmaceutical inhibitors, and the most common structural similarity, in addition to the stilbene backbone, was the presence of the 4-hydroxy phenyl group. Stilbene products found to act as inhibitors at the estrogen receptor include a group of plant-derived compounds including resveratrol, a dietary supplement, and DSBP a fluorescent whitening agent that is a common textile detergent additive. The presence of pharmaceuticals and personal care products in the environment will challenge traditional models and risk assessment frameworks for predicting effects due to their upredictable effects at low doses and atypical environmental behavior.
機(jī)譯：在污水和地表水中已檢測(cè)到與二苯乙烯相關(guān)的藥物和個(gè)人護(hù)理產(chǎn)品。使用卵黃蛋白原生物標(biāo)志物測(cè)試在體外對(duì)人雌激素受體和虹鱒魚(yú)雌激素受體測(cè)試了一套與二苯乙烯有關(guān)的個(gè)人護(hù)理產(chǎn)品和藥品的效果，并在體內(nèi)對(duì)虹鱒魚(yú)的雌激素受體進(jìn)行了測(cè)試。結(jié)果表明，這些化合物中的許多化合物的行為與已知的藥物抑制劑相似，除二苯乙烯骨架外，最常見(jiàn)的結(jié)構(gòu)相似性是4-羥基苯基的存在。被發(fā)現(xiàn)在雌激素受體上起抑制劑作用的二苯乙烯產(chǎn)品包括一組植物來(lái)源的化合物，包括白藜蘆醇，膳食補(bǔ)充劑和DSBP熒光增白劑，后者是一種常見(jiàn)的紡織品洗滌劑添加劑。環(huán)境中藥品和個(gè)人護(hù)理產(chǎn)品的存在將挑戰(zhàn)傳統(tǒng)的模型和風(fēng)險(xiǎn)評(píng)估框架，因?yàn)樗鼈冊(cè)诘蛣┝亢头堑湫偷沫h(huán)境行為下具有可預(yù)測(cè)的作用，因此可預(yù)測(cè)作用。

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  • 作者

    Simmons, Denina B. D.;

  • 作者單位

    Trent University (Canada).;

  • 授予單位 Trent University (Canada).;
  • 學(xué)科 Health Sciences Toxicology.
  • 學(xué)位 M.Sc.
  • 年度 2006
  • 頁(yè)碼 108 p.
  • 總頁(yè)數(shù) 108
  • 原文格式 PDF
  • 正文語(yǔ)種 eng
  • 中圖分類 毒物學(xué)（毒理學(xué)）;
  • 關(guān)鍵詞

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