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首頁> 外文學位 >The impact of school based anti-malarial treatment on adolescents' cognition: Evidence from a cluster-randomized intervention in Kenya.
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The impact of school based anti-malarial treatment on adolescents' cognition: Evidence from a cluster-randomized intervention in Kenya.

機譯：基于學校的抗瘧疾治療對青少年認知的影響：來自肯尼亞的整群隨機干預的證據。

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摘要

Children's health is an important factor that influences their success in education---poor health, especially when induced by disease, has been linked to poorer cognitive performance, particularly among children across the developing world (Behrman, 1996; UNESCO, 2008; Jukes et al., 2008). One health concern, particularly for sub-Saharan Africa, that has been shown to limit children's cognitive functioning is malaria, a disease whose cognitive effects can be mitigated via mass anti-malaria treatment, also known as intermittent preventative treatment (IPT). In my dissertation, I analyze data from a cohort of 916 Kenyan adolescents, aged 11--16, participating in a cluster randomized trial of a school-based IPT program and examine how the cognitive growth rates---as measured on two tests of sustained attention---of particular subgroups of adolescents with and at risk of malaria differ in response to IPT. I also estimate the impact of receiving a specific dosage amount of IPT on their cognitive functioning.;Based on my analyses using multilevel growth modeling, I find that adolescents who were randomly offered IPT experience faster cognitive growth rates than their peers who were offered a placebo; moreover, adolescents harboring a parasitic infection at baseline, S. mansoni, experience the fastest cognitive growth. My findings based on the method of instrumental variables (IV) reveal that the cognitive functioning of children who receive a total of seven or more (up to nine) doses of IPT is significantly higher than their peers who receive six or fewer doses. In addition, adolescents with S. mansoni at baseline and treated with seven or more IPT doses have cognitive scores that are higher than their peers without S. mansoni.;Overall, my analyses show that IPT can significantly improve the sustained attention of adolescents who face potential detriments in their cognitive functioning due to malaria and malaria-related diseases. In particular, adolescents who have S. mansoni at baseline experience the largest overall cognitive gains from IPT. By improving adolescents' sustained attention, they may have an enhanced capacity for learning which can have consequences for the overall livelihood that may extend well into their futures.
機譯：兒童的健康是影響他們在教育上取得成功的重要因素，尤其是在疾病引起的情況下，不良的健康與較差的認知能力有關，尤其是在發(fā)展中國家的兒童中（Behrman，1996； UNESCO，2008； Jukes等）等（2008年）。瘧疾是一種特別關注撒哈拉以南非洲的健康問題，已被證明會限制兒童的認知功能。瘧疾是一種可以通過大規(guī)模抗瘧疾治療（也稱為間歇性預防治療（IPT））減輕其認知影響的疾病。在我的論文中，我分析了來自916名11--16歲肯尼亞青少年的數據，他們參加了一項基于學校的IPT計劃的整群隨機試驗，并研究了認知增長率是如何通過兩次測試得出的。持續(xù)的關注-對IPT的反應不同的青少年人群以及有瘧疾風險的青少年也有所不同。我還估計了接受特定劑量IPT對其認知功能的影響?；谖沂褂枚嗉壣L模型進行的分析，我發(fā)現隨機提供IPT的青少年比接受安慰劑的青少年經歷更快的認知增長;此外，在基線時有寄生蟲感染的曼氏沙門氏菌的青少年認知增長最快。根據工具變量（IV）的方法，我的發(fā)現表明，總共接受7劑或更多（最多9劑）IPT的兒童的認知功能明顯高于接受6劑或更少劑量的同齡兒童的認知功能。此外，基線時使用曼氏葡萄球菌并接受7次或更多IPT劑量治療的青少年的認知得分高于沒有曼氏葡萄球菌的同齡人。總體而言，我的分析表明，IPT可以顯著提高面對這些疾病的青少年的持續(xù)注意力瘧疾和與瘧疾有關的疾病可能會損害他們的認知功能。特別是，在基線時患有曼氏鏈球菌的青少年從IPT獲得最大的整體認知增益。通過提高青少年的持續(xù)關注力，他們可能具有增強的學習能力，這可能對總體生計產生影響，并可能延伸到他們的未來。

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  • 作者

    Gee, Kevin A.;

  • 作者單位

    Harvard University.;

  • 授予單位 Harvard University.;
  • 學科 Education Administration.;Health Sciences Public Health.;Education Educational Psychology.
  • 學位 Ed.D.
  • 年度 2010
  • 頁碼 97 p.
  • 總頁數 97
  • 原文格式 PDF
  • 正文語種 eng
  • 中圖分類
  • 關鍵詞

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