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Risk assessment of selective serotonin reuptake inhibitors: Comparing methods in tiered environmental risk assessment.

機(jī)譯：選擇性5-羥色胺再攝取抑制劑的風(fēng)險(xiǎn)評估：分層環(huán)境風(fēng)險(xiǎn)評估中的比較方法。

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Environmental detection of pharmaceuticals, including the selective serotonin reuptake inhibitor (SSRI) fluoxetine, has reinforced the need for environmental exposure, fate, effects, and hazard assessment of these chemicals. Environmental concentrations of SSRIs were predicted using current methodologies and compared to available measured environmental concentrations. The environmental fate of SSRIs fluoxetine, fluvoxamine, and sertraline was evaluated in microcosm model ecosystems; toxicity to algae and fish was evaluated at different tiers consisting of (quantitative) structure activity relationships, acute laboratory toxicity assays, and in microcosm model ecosystems. Hazard to fish and algae was evaluated using predicted environmental concentrations and toxicity values determined at each tier. The hazard at each tier was then compared to generate data-driven uncertainty factors (UFs) for extrapolation between tiers which were then used to extrapolate the additional hazard of the remaining SSRIs: citalopram and paroxetine. Furthermore, the utility of species sensitivity distributions (SSDs) and interspecies correlation estimation (ICE) was investigated as extrapolation methods and compared to pragmatic UFs. Overall, algae were found to be more sensitive than fish to SSRIs with sertraline being the most toxic of the SSRIs tested followed by fluoxetine and fluvoxamine. However, the hazard of SSRIs at current environmental concentrations is low. Moreover, SSDs and ICE show promise as extrapolation tools as they generated conservative hazard estimates that were more accurate than those derived using pragmatic UFs.

機(jī)譯：藥物的環(huán)境檢測，包括選擇性5-羥色胺再攝取抑制劑（SSRI）氟西汀，已經(jīng)增加了對這些化學(xué)品的環(huán)境暴露，命運(yùn)，影響和危害評估的需求。使用目前的方法可以預(yù)測SSRI的環(huán)境濃度，并將其與可用的測量環(huán)境濃度進(jìn)行比較。在縮影模型生態(tài)系統(tǒng)中評估了SSRIs氟西汀，氟伏沙明和舍曲林的環(huán)境命運(yùn)；對藻類和魚類的毒性進(jìn)行了不同級別的評估，包括（定量）結(jié)構(gòu)活性關(guān)系，急性實(shí)驗(yàn)室毒性分析以及微觀世界模型生態(tài)系統(tǒng)。使用預(yù)測的環(huán)境濃度和在每一層確定的毒性值來評估對魚類和藻類的危害。然后比較每個(gè)層級上的危害，以生成數(shù)據(jù)驅(qū)動的不確定性因素（UFs）進(jìn)行層間推斷，然后將其用于推斷剩余SSRI（西酞普蘭和帕羅西?。┑钠渌：?。此外，物種敏感性分布（SSD）和種間相關(guān)估計(jì)（ICE）的實(shí)用性作為外推方法進(jìn)行了研究，并與實(shí)用UF進(jìn)行了比較?？傮w而言，發(fā)現(xiàn)藻類比魚類對SSRI更敏感，其中舍曲林是被測試的SSRI中毒性最高的，其次是氟西汀和氟伏沙明。但是，在當(dāng)前環(huán)境濃度下，SSRI的危害很小。而且，SSD和ICE有望作為外推工具，因?yàn)樗鼈兩傻谋Ｊ匚：烙?jì)值比使用務(wù)實(shí)UF得出的估計(jì)值更為準(zhǔn)確。

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作者
Johnson, David J.;
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作者單位

University of Guelph (Canada).;

展開▼
授予單位 University of Guelph (Canada).;
學(xué)科 Health Sciences Toxicology.; Biology Neuroscience.
學(xué)位 M.Sc.
年度 2004
頁碼 112 p.
總頁數(shù) 112
原文格式 PDF
正文語種 eng
中圖分類毒物學(xué)（毒理學(xué)）;神經(jīng)科學(xué);
關(guān)鍵詞

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Risk assessment of selective serotonin reuptake inhibitors: Comparing methods in tiered environmental risk assessment.

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