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首頁> 外文學位 >High Resolution Cardiac Magnetic Resonance Elastography: From Phantom to Mouse Heart.
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High Resolution Cardiac Magnetic Resonance Elastography: From Phantom to Mouse Heart.

機譯：高分辨率心臟磁共振彈性成像：從幻影到小鼠心臟。

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摘要

First proposed in 1995, magnetic resonance elastography (MRE) has attracted more and more attention with its capability of estimating soft tissue stiffness non-invasively. In addition to the FDA-certified application for hepatic disease diagnosis, MRE has been studied in multiple organs as a potential new biomarker in various disease diagnoses, especially in recent years. Beside the application to disease diagnosis, MRE has also been utilized in monitoring the development of engineered tissue and in more fundamental studies of tissue viscoelasticity.;This dissertation aims to advance the application of high field MRE on complex anatomical structures, beginning with phantom studies progressing to, arguably, the most complex application yet attempted, cardiac MRE in vivo on a mouse model to assess myocardial stiffness in healthy and pathological subjects. Prior to attempting in vivo cardiac MRE on the mouse model, several pilot studies were conducted on phantom models to advance the technique.;A wideband phantom study was conducted to improve viscoelastic model identification. In order to better understand mechanical wave motion in geometry similar to the left ventricle, MRE experiments on a liquid-filled spherical shell phantom embedded in a soft tissue mimicking material were also conducted. Computational finite element simulations on a three dimensional model of a mouse with different actuation methods were also performed to improve understanding of how mechanical waves propagate into the complicated geometry of the mouse body, and how the tissue responds under different actuation approaches. An in vivo mouse cardiac MRE technique was then developed and tested on a healthy mouse model. This technique is able to track expected stiffness changes in the myocardium as a function of the cardiac cycle. And the results showed the feasibility of this implementation of in vivo cardiac MRE on mice. A follow-up study of applying the cardiac MRE on a Myocardial Infarcted (MI) mouse model was then conducted to assess the ability to noninvasively quantify expected changes in the myocardial mechanical properties of these animals, relative to the healthy cases.
機譯：磁共振彈性成像（MRE）于1995年首次提出，以其非侵入性的方式估計軟組織硬度的能力吸引了越來越多的關注。除了經(jīng)FDA認證的肝病診斷應用程序外，還已經(jīng)在多個器官中對MRE進行了研究，作為各種疾病診斷中潛在的新生物標記，尤其是近年來。除了在疾病診斷中的應用外，MRE還被用于監(jiān)測工程組織的發(fā)展以及組織粘彈性的更基礎的研究。本論文旨在推動高場MRE在復雜解剖結構上的應用，從幻象研究開始可以說是迄今為止尚未嘗試過的最復雜的應用，即在小鼠模型上體內進行心臟MRE評估健康和病理對象的心肌僵硬程度。在嘗試在小鼠模型上進行體內心臟MRE之前，先對體模模型進行了一些初步研究以改進該技術。進行了寬帶體模研究以改善粘彈性模型的識別。為了更好地理解類似于左心室的幾何形狀中的機械波運動，還對嵌入在軟組織模擬材料中的液體填充球形殼模型進行了MRE實驗。還使用不同的驅動方法對鼠標的三維模型進行了計算有限元模擬，以增進對機械波如何傳播到鼠標主體的復雜幾何形狀以及組織在不同的驅動方式下的響應方式的了解。然后開發(fā)了體內小鼠心臟MRE技術，并在健康的小鼠模型上進行了測試。該技術能夠追蹤心肌的預期硬度隨心動周期的變化。結果表明，在小鼠上實施體內心臟MRE的可行性。然后進行了將心臟MRE應用于心肌梗塞（MI）小鼠模型的后續(xù)研究，以評估相對于健康病例，無創(chuàng)量化這些動物的心肌力學特性預期變化的能力。

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  • 作者

    Liu, Yifei.;

  • 作者單位

    University of Illinois at Chicago.;

  • 授予單位 University of Illinois at Chicago.;
  • 學科 Mechanical engineering.;Medical imaging.;Biomedical engineering.
  • 學位 Ph.D.
  • 年度 2015
  • 頁碼 162 p.
  • 總頁數(shù) 162
  • 原文格式 PDF
  • 正文語種 eng
  • 中圖分類 遙感技術;
  • 關鍵詞

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