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首頁> 外文學位 >Comparison of linear, bi-dimensional and volumetric measurements in evaluating tumor response of Hepatocellular carcinoma lesions in the arterial and portal venous phases on MRI.
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Comparison of linear, bi-dimensional and volumetric measurements in evaluating tumor response of Hepatocellular carcinoma lesions in the arterial and portal venous phases on MRI.

機譯：在MRI上評估動脈，門靜脈期肝細胞癌病變的線性，二維和體積測量結果的比較。

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摘要

There are unmet needs in evaluating treatment response of hepatocellular carcinoma in research protocols. Early predictors, such as imaging biomarkers, could allow for earlier judgment of treatment effect. Currently RECIST is the most widely accepted criterion in clinical trials. A modified RECIST (mRECIST) criterion was developed to take into account the unique imaging characteristics of HCC lesions. Much discussion has occurred regarding linear measurements and their appropriateness for evaluating change in tumor burden over time. The simplicity of currently accepted criteria differs with the increasing sophistication of imaging techniques. Tumor volume change on 3D imaging can provide insight into actual action of treatment rather than an estimate of action as shown by linear and bi-dimensional measurements. It was the aim of this study to determine whether linear, bi-dimensional, and volumetric percent changes of HCC lesions, in both the arterial and portal venous phases, are significantly comparable.;27 HCC lesions (identified on 25 subjects) were measured at two timepoints by each method on 3D GRE MRI scans in both phases. Percent change was calculated per lesion for each measurement type in both the arterial and portal venous phases. Signed rank tests, paired t tests, and comparison of change tests were run to evaluate the data.;Significant differences between the percent changes of linear measurements versus volumetric measurements were observed using a Wilcoxon signed-rank test which showed p = 0.0000. A simple correlation assessment showed positive correlations for all measurements, with the lowest being correlations 0.8679 for the arterial linear percent change versus the arterial volumetric percent change and 0.8434 for the portal venous linear percent change versus the portal venous volumetric percent change. Differences between percent changes of linear versus bi-dimensional measurements and bi-dimensional versus volumetric measurements were significant as well (Linear versus bi-dimensional p = 0.0001, bi-dimensional versus volumetric p = 0.0004).;To conclude, the differences in the percent changes when comparing the measurement types are statistically significant, particularly when comparing linear and volumetric measurements. Establishing a reproducible volumetric criterion could lead to improvements in the implementation of clinical trials.
機譯：在研究方案中評估肝細胞癌的治療反應存在未滿足的需求。早期預測因素，例如成像生物標志物，可以允許較早判斷治療效果。當前，RECIST是臨床試驗中最廣泛接受的標準?？紤]到HCC病變的獨特影像學特征，制定了改良的RECIST（mRECIST）標準。關于線性測量及其用于評估腫瘤負荷隨時間變化的適當性，已經(jīng)進行了很多討論。當前接受的標準的簡單性隨成像技術的日益復雜而不同。 3D成像上的腫瘤體積變化可以提供對治療實際作用的洞察力，而不是線性和二維測量結果所顯示的作用估計。這項研究的目的是確定在動脈和門靜脈期的肝癌病變的線性，二維和體積百分比變化是否具有顯著可比性。在以下位置測量了27例HCC病變（在25名受試者中確定）在兩個階段中，每種方法在3D GRE MRI掃描中分別使用兩個時間點。計算動脈和門靜脈期每種測量類型的每個病變的百分比變化。進行有符號秩檢驗，配對t檢驗和變化比較檢驗以評估數(shù)據(jù)。使用Wilcoxon有符號秩檢驗，觀察到線性測量值與體積測量值的百分比變化之間存在顯著差異，p = 0.0000。一個簡單的相關性評估顯示所有測量值均呈正相關，最低的是動脈線性百分比變化與動脈體積百分比變化的相關系數(shù)為0.8679，而門靜脈線性百分比變化與門靜脈體積百分比變化的相關系數(shù)為0.8434。線性測量與二維測量的百分比變化之間以及二維測量與體積測量的百分比變化之間的差異也很顯著（線性與二維p = 0.0001，二維與體積p = 0.0004）。比較測量類型時的百分比變化具有統(tǒng)計顯著性，尤其是在比較線性和體積測量時。建立可重復的體積標準可以改善臨床試驗的實施。

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  • 作者

    Pratt, Michelle Sherman.;

  • 作者單位

    Boston University.;

  • 授予單位 Boston University.;
  • 學科 Medical imaging.;Oncology.
  • 學位 M.S.
  • 年度 2015
  • 頁碼 55 p.
  • 總頁數(shù) 55
  • 原文格式 PDF
  • 正文語種 eng
  • 中圖分類
  • 關鍵詞

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