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Association between gait characteristics and endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease

機譯：有癥狀外周動脈疾病患者步態(tài)特征與內(nèi)皮氧化應(yīng)激和炎癥之間的關(guān)系

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The aim of the study was to determine whether gait characteristics were associated with endothelial cell inflammation, oxidative stress, and apoptosis and with circulating biomarkers of inflammation and antioxidant capacity in older patients with symptomatic peripheral artery disease (PAD). Gait measurements of 231 symptomatic men and women with PAD were assessed during a 4-m walk test. Patients were further characterized on endothelial effects of circulating factors present in the sera using a cell culture-based bioassay on primary human arterial endothelial cells and on circulating inflammatory and vascular biomarkers. In a multivariate regression model for gait speed, the significant independent variables were age (p < 0.001), intercellular cell adhesion molecule-1 (ICAM-1) (p < 0.001), diabetes (p = 0.003), sex (p = 0.003), and history of cerebrovascular accidents (p = 0.021). In multivariate analyses for gait cadence, the significant independent predictors included high-sensitivity C-reactive protein (HsCRP) (p < 0.001), diabetes (p = 0.001), and hypertension (p = 0.001). In a multivariate regression model for gait stride length, the significant independent variables were HsCRP (p < 0.001), age (p < 0.001), ICAM-1 (p < 0.001), hypertension (p = 0.002), cellular reactive oxygen species production (p = 0.007), and sex (p = 0.008). Higher levels of circulating biomarkers of inflammation and endothelial cell oxidative stress were associated with slower gait speed, slower cadence, and shorter stride length in older symptomatic patients with PAD. Additionally, this profile of impaired gait was more evident in older patients, in women, and in those with diabetes, hypertension, and history of cerebrovascular accidents.
機譯：該研究的目的是確定老年有癥狀的外周動脈疾?。≒AD）患者的步態(tài)特征是否與內(nèi)皮細胞炎癥，氧化應(yīng)激和細胞凋亡以及炎癥和抗氧化能力的循環(huán)生物標(biāo)志物有關(guān)。在4 m步行測試中評估了231名有癥狀的PAD男女的步態(tài)測量。使用基于細胞培養(yǎng)的生物測定法對患者的原發(fā)性人類動脈內(nèi)皮細胞以及循環(huán)炎癥和血管生物標(biāo)記物，進一步表征患者血清中循環(huán)因子的內(nèi)皮作用。在步態(tài)速度的多元回歸模型中，重要的獨立變量是年齡（p <0.001），細胞間細胞粘附分子1（ICAM-1）（p <0.001），糖尿病（p = 0.003），性別（p = 0.003） ）以及腦血管意外的病史（p = 0.021）。在步態(tài)節(jié)奏的多變量分析中，重要的獨立預(yù)測因素包括高敏感性C反應(yīng)蛋白（HsCRP）（p <0.001），糖尿?。╬ = 0.001）和高血壓（p = 0.001）。在步態(tài)步長的多元回歸模型中，重要的獨立變量是HsCRP（p <0.001），年齡（p <0.001），ICAM-1（p <0.001），高血壓（p = 0.002），細胞活性氧物質(zhì)產(chǎn)生（p = 0.007）和性別（p = 0.008）。老年有癥狀的PAD患者中，炎癥和內(nèi)皮細胞氧化應(yīng)激的循環(huán)生物標(biāo)志物水平較高，與步態(tài)速度較慢，步伐較慢和步幅較短有關(guān)。此外，這種步態(tài)受損的情況在老年患者，女性以及患有糖尿病，高血壓和腦血管意外史的患者中更為明顯。

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