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Large-Scale Fusion of Gray Matter and Resting-State Functional MRI Reveals Common and Distinct Biological Markers across the Psychosis Spectrum in the B-SNIP Cohort

機(jī)譯：灰度物質(zhì)和靜息態(tài)功能性MRI的大規(guī)模融合揭示了B-SNIP人群精神病譜中常見(jiàn)和不同的生物學(xué)標(biāo)記

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To investigate whether aberrant interactions between brain structure and function present similarly or differently across probands with psychotic illnesses [schizophrenia (SZ), schizoaffective disorder (SAD), and bipolar I disorder with psychosis (BP)] and whether these deficits are shared with their first-degree non-psychotic relatives. A total of 1199 subjects were assessed, including 220 SZ, 147 SAD, 180 psychotic BP, 150 first-degree relatives of SZ, 126 SAD relatives, 134 BP relatives, and 242 healthy controls (). All subjects underwent structural MRI (sMRI) and resting-state functional MRI (rs-fMRI) scanning. Joint-independent component analysis (jICA) was used to fuse sMRI gray matter and rs-fMRI amplitude of low-frequency fluctuations data to identify the relationship between the two modalities. jICA revealed two significantly fused components. The association between functional brain alteration in a prefrontal–striatal–thalamic–cerebellar network and structural abnormalities in the default mode network was found to be common across psychotic diagnoses and correlated with cognitive function, social function, and schizo-bipolar scale scores. The fused alteration in the temporal lobe was unique to SZ and SAD. The above effects were not seen in any relative group (including those with cluster-A personality). Using a multivariate-fused approach involving two widely used imaging markers, we demonstrate both shared and distinct biological traits across the psychosis spectrum. Furthermore, our results suggest that the above traits are psychosis biomarkers rather than endophenotypes.
機(jī)譯：調(diào)查精神病患者[精神分裂癥（SZ），精神分裂性障礙（SAD）和精神病雙相I型障礙（BP）]的先證者大腦結(jié)構(gòu)與功能之間的異常相互作用是否相似或不同，以及這些缺陷是否與他們的第一個(gè)共同度非精神病親戚。共評(píng)估了1199名受試者，包括220名SZ，147名SAD，180名精神病性BP，150名SZ一級(jí)親屬，126名SAD親戚，134名BP親戚和242名健康對(duì)照者（）。所有受試者均接受結(jié)構(gòu)性MRI（sMRI）和靜息狀態(tài)功能性MRI（rs-fMRI）掃描。使用聯(lián)合獨(dú)立成分分析（jICA）融合sMRI灰質(zhì)和低頻波動(dòng)數(shù)據(jù)的rs-fMRI振幅，以識(shí)別這兩種模態(tài)之間的關(guān)系。 jICA發(fā)現(xiàn)了兩個(gè)明顯融合的成分。發(fā)現(xiàn)前額葉-紋狀體-丘腦-小腦網(wǎng)絡(luò)中功能性大腦改變與默認(rèn)模式網(wǎng)絡(luò)中的結(jié)構(gòu)異常之間的關(guān)聯(lián)在精神病診斷中很常見(jiàn)，并且與認(rèn)知功能，社交功能和精神分裂癥-雙極性量表評(píng)分相關(guān)。顳葉的融合改變是SZ和SAD特有的。在任何相對(duì)群體（包括具有A型性格的人）中均未觀察到上述效應(yīng)。使用涉及兩個(gè)廣泛使用的影像標(biāo)記物的多元融合方法，我們證明了精神病譜圖中共有和不同的生物學(xué)特征。此外，我們的結(jié)果表明上述特征是精神病的生物標(biāo)志物，而不是內(nèi)表型。

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