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Effect of Heweianshen Decoction on Orexin-A and Cholecystokinin-8 Expression in Rat Models of Insomnia

機(jī)譯：合胃安神湯對(duì)失眠模型大鼠食欲素A和膽囊收縮素8表達(dá)的影響

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Objective. To study the effect of Heweianshen decoction (HAD) on orexin-A and cholecystokinin-8 (CCK-8) expression in rat models of insomnia caused by injecting parachlorophenylalanine (PCPA) intraperitoneally. Methods. Fifty male Wistar rats were randomly divided into five groups (10 rats in each group): blank group, model group, and low-, medium-, and high-dose HAD-treated groups. A rat model of insomnia was established by injecting intraperitoneally with PCPA (300 mg/kg body weight). Rats were given normal saline (10 mL/kg) or 5.25, 10.5, and 21 g/kg HAD by intragastric administration once a day for 6 days. After that, the rats were sacrificed to collect the hypothalamus for tests, using radioimmunoassay to detect the expression of orexin-A and CCK-8. Results. Heweianshen decoction reduced the expression of orexin-A and increased the expression of CCK-8 in the hypothalamus of rat model of insomnia. Conclusion. The therapeutic effect of HAD on insomnia is partially attributed to the decreased expression of orexin-A and increased expression of CCK-8.
機(jī)譯：目的。目的研究和胃腎腎湯（HAD）對(duì)腹腔注射對(duì)氯苯丙氨酸（PCPA）致失眠大鼠模型中orexin-A和膽囊收縮素8（CCK-8）表達(dá)的影響。方法。將五十只雄性Wistar大鼠隨機(jī)分為五組（每組十只大鼠）：空白組，模型組以及低，中和高劑量HAD治療組。通過腹膜內(nèi)注射PCPA（300μmg/ kg體重）建立失眠的大鼠模型。每天一次通過胃內(nèi)給藥給予大鼠生理鹽水（10μmL/ kg）或5.25、10.5和21μg/ kg HAD，連續(xù)6天。之后，處死大鼠以收集下丘腦以進(jìn)行測(cè)試，使用放射免疫測(cè)定法檢測(cè)orexin-A和CCK-8的表達(dá)。結(jié)果。和味安神湯能降低失眠大鼠下丘腦中orexin-A的表達(dá)，并增加CCK-8的表達(dá)。結(jié)論。 HAD對(duì)失眠的治療作用部分歸因于orexin-A的表達(dá)減少和CCK-8的表達(dá)增加。

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