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首頁> 美國衛(wèi)生研究院文獻(xiàn)>Saudi Pharmaceutical Journal : SPJ >An alternative approach to wound healing field; new composite films from natural polymers for mupirocin dermal delivery
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An alternative approach to wound healing field; new composite films from natural polymers for mupirocin dermal delivery

機(jī)譯：傷口愈合領(lǐng)域的另一種方法；天然聚合物制成的新型復(fù)合膜可用于莫匹羅星的皮膚遞送

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摘要

In this study, novel adhesive films were prepared for Mupirocin dermal delivery. Natural polymers as chitosan, sodium alginate and carbopol were used for films development to evaluate possible interactions and drug release properties. Solvent evaporation method was used for films preparation. Preliminary studies involved FT-IR spectroscopy and Scanning Electron Microscopy to specify interactions and morphology. Thickness, tensile strength and water uptake in phosphate buffer saline were evaluated whereas in vitro release studies were also performed. In vitro drug release studies demonstrated that mupirocin release was improved. Ex vivo bioadhesion and permeation studies using Balb-c mice were performed to check the suitability of the films. Antimicrobial ability was evaluated by agar well diffusion tests. Finally, excisional wound model applied to test the wound healing effect and evaluated macroscopic and histopathologically. One formulation was found more effective compared to the market product for wound healing at Balb-c mice.
機(jī)譯：在這項(xiàng)研究中，制備了新型的粘性薄膜用于莫匹羅星皮膚遞送。天然聚合物，如殼聚糖，海藻酸鈉和卡波姆被用于膠片顯影，以評(píng)估可能的相互作用和藥物釋放特性。使用溶劑蒸發(fā)法制備膜。初步研究涉及FT-IR光譜學(xué)和掃描電子顯微鏡，以規(guī)定相互作用和形態(tài)。評(píng)價(jià)了磷酸鹽緩沖鹽水的厚度，抗張強(qiáng)度和吸水率，同時(shí)還進(jìn)行了體外釋放研究。體外藥物釋放研究表明莫匹羅星的釋放得到改善。使用Balb-c小鼠進(jìn)行了離體生物粘附和滲透研究，以檢查薄膜的適用性。通過瓊脂孔擴(kuò)散測試評(píng)估抗菌能力。最后，切除傷口模型用于測試傷口愈合效果，并進(jìn)行肉眼和組織病理學(xué)評(píng)估。發(fā)現(xiàn)一種配方與市售產(chǎn)品相比對(duì)Balb-c小鼠的傷口愈合更有效。

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