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首頁> 美國衛(wèi)生研究院文獻>Plant Physiology >Focus Issue on Plant Databases: BioMOBY Successfully Integrates Distributed Heterogeneous Bioinformatics Web Services. The PlaNet Exemplar Case
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Focus Issue on Plant Databases: BioMOBY Successfully Integrates Distributed Heterogeneous Bioinformatics Web Services. The PlaNet Exemplar Case

機譯：植物數(shù)據(jù)庫上的焦點問題：BioMOBY成功地集成了分布式異構生物信息學Web服務。 PlaNet示例案例

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The burden of noninteroperability between on-line genomic resources is increasingly the rate-limiting step in large-scale genomic analysis. BioMOBY is a biological Web Service interoperability initiative that began as a retreat of representatives from the model organism database community in September, 2001. Its long-term goal is to provide a simple, extensible platform through which the myriad of on-line biological databases and analytical tools can offer their information and analytical services in a fully automated and interoperable way. Of the two branches of the larger BioMOBY project, the Web Services branch (MOBY-S) has now been deployed over several dozen data sources worldwide, revealing some significant observations about the nature of the integrative biology problem; in particular, that Web Service interoperability in the domain of bioinformatics is, unexpectedly, largely a syntactic rather than a semantic problem. That is to say, interoperability between bioinformatics Web Services can be largely achieved simply by specifying the data structures being passed between the services (syntax) even without rich specification of what those data structures mean (semantics). Thus, one barrier of the integrative problem has been overcome with a surprisingly simple solution. Here, we present a nontechnical overview of the critical components that give rise to the interoperable behaviors seen in MOBY-S and discuss an exemplar case, the PlaNet consortium, where MOBY-S has been deployed to integrate the on-line plant genome databases and analytical services provided by a European consortium of databases and data service providers.
機譯：在線基因組資源之間不可互操作性的負擔越來越成為大規(guī)模基因組分析中的限速步驟。 BioMOBY是一項生物Web服務互操作性計劃，始于2001年9月來自模型生物數(shù)據(jù)庫社區(qū)的代表撤退。其長期目標是提供一個簡單，可擴展的平臺，通過該平臺，可以使用各種在線生物數(shù)據(jù)庫和分析工具可以完全自動化和可互操作的方式提供其信息和分析服務。在較大的BioMOBY項目的兩個分支中，Web服務分支（MOBY-S）現(xiàn)在已在全球范圍內部署了數(shù)十個數(shù)據(jù)源，其中揭示了有關整合生物學問題性質的一些重要發(fā)現(xiàn)。特別是，出乎意料的是，生物信息學領域的Web Service互操作性在很大程度上是句法而非語義問題。也就是說，即使不詳細說明這些數(shù)據(jù)結構的含義（語義），只需指定服務之間傳遞的數(shù)據(jù)結構（語法），就可以在很大程度上實現(xiàn)生物信息Web服務之間的互操作性。因此，通過令人驚訝的簡單解決方案克服了集成問題的一個障礙。在這里，我們將對引起MOBY-S中出現(xiàn)的互操作行為的關鍵組件進行非技術性概述，并討論一個示例案例PlaNet聯(lián)盟，在該案例中，MOBY-S已被部署來集成在線植物基因組數(shù)據(jù)庫和歐洲數(shù)據(jù)庫和數(shù)據(jù)服務提供商聯(lián)盟提供的分析服務。

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