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首頁> 美國衛(wèi)生研究院文獻(xiàn)>Journal of Translational Medicine >Quantitative characterization of androgen receptor protein expression and cellular localization in circulating tumor cells from patients with metastatic castration-resistant prostate cancer
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Quantitative characterization of androgen receptor protein expression and cellular localization in circulating tumor cells from patients with metastatic castration-resistant prostate cancer

機(jī)譯：轉(zhuǎn)移性去勢(shì)抵抗性前列腺癌患者循環(huán)腫瘤細(xì)胞中雄激素受體蛋白表達(dá)的定量表征和細(xì)胞定位

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BackgroundMany current therapies for metastatic castration-resistant prostate cancer (mCRPC) are aimed at AR signaling; however, resistance to these therapies is inevitable. To personalize CRPC therapy in an individual with clinical progression despite maximal AR signaling blockade, it is important to characterize the status of AR activity within their cancer. Biopsies of bone metastases are invasive and frequently fail to yield sufficient tissue for further study. Evaluation of circulating tumor cells (CTCs) offers an alternative, minimally invasive mechanism to characterize and study late-stage disease. The goal of this study was to evaluate the utility of CTC interrogation with respect to the AR as a potential novel therapeutic biomarker in patients with mCRPC.
機(jī)譯：背景技術(shù)目前，許多針對(duì)轉(zhuǎn)移性去勢(shì)抵抗性前列腺癌（mCRPC）的療法均針對(duì)AR信號(hào)傳導(dǎo)。然而，對(duì)這些療法的抵抗是不可避免的。盡管有最大的AR信號(hào)傳導(dǎo)阻滯，但要在具有臨床進(jìn)展的個(gè)體中個(gè)性化CRPC治療，重要的是表征其癌癥內(nèi)AR活性的狀態(tài)。骨轉(zhuǎn)移活檢是侵入性的，通常無法產(chǎn)生足夠的組織用于進(jìn)一步研究。循環(huán)腫瘤細(xì)胞（CTC）的評(píng)估提供了另一種微創(chuàng)機(jī)制來表征和研究晚期疾病。這項(xiàng)研究的目的是評(píng)估關(guān)于AR的CTC詢問作為mCRPC患者潛在的新型治療生物標(biāo)志物的效用。

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