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Nanosized Zinc Oxide Induces Toxicity in Human Lung Cells

機(jī)譯：納米氧化鋅誘導(dǎo)人肺細(xì)胞毒性。

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Zinc oxide nanoparticles (ZnO-NPs) are increasingly used in sunscreens, biosensors, food additives, pigments, rubber manufacture, and electronic materials. With the wide application of ZnO-NPs, concern has been raised about its unintentional health and environmental impacts. This study investigates the toxic effects of ZnO-NPs in human lung cells. In order to assess toxicity, human lung epithelial cells (L-132) were exposed to dispersion of 50 nm ZnO-NPs at concentrations of 5, 25, 50, and 100 μg/mL for 24 h. The toxicity was evaluated by observing changes in cell morphology, cell viability, oxidative stress parameters, DNA damage analysis, and gene expression. Exposure to 50 nm ZnO-NPs at concentrations between 5 and 100 μg/mL decreased cell viability in a concentration-dependent manner. Morphological examination revealed cell shrinkage, nuclear condensation, and formation of apoptotic bodies. The oxidative stress parameters revealed significant depletion of GSH level and increase in ROS levels suggesting generation of oxidative stress. ZnO-NPs exposure caused DNA fragmentation demonstrating apoptotic type of cell death. ZnO-NPs increased the expression of metallothionein gene, which is considered as a biomarker in metal-induced toxicity. To summarize, ZnO-NPs cause toxicity in human lung cells possibly through oxidative stress-induced apoptosis.
機(jī)譯：氧化鋅納米顆粒（ZnO-NPs）越來越多地用于防曬霜，生物傳感器，食品添加劑，顏料，橡膠制造和電子材料中。隨著ZnO-NP的廣泛應(yīng)用，人們對(duì)其非故意的健康和環(huán)境影響提出了關(guān)注。這項(xiàng)研究調(diào)查了ZnO-NP在人肺細(xì)胞中的毒性作用。為了評(píng)估毒性，將人肺上皮細(xì)胞（L-132）暴露于濃度為5、25、50和100μg/ mL的50μnmZnO-NPs分散液中24μh。通過觀察細(xì)胞形態(tài)，細(xì)胞活力，氧化應(yīng)激參數(shù)，DNA損傷分析和基因表達(dá)的變化來評(píng)估毒性。濃度在5至100μg/ mL之間的50μnmZnO-NPs暴露會(huì)以濃度依賴性方式降低細(xì)胞活力。形態(tài)學(xué)檢查顯示細(xì)胞縮小，核濃縮和凋亡小體形成。氧化應(yīng)激參數(shù)顯示GSH水平顯著耗竭，ROS水平升高，表明產(chǎn)生了氧化應(yīng)激。 ZnO-NPs暴露引起DNA片段化，表明細(xì)胞凋亡類型為細(xì)胞死亡。 ZnO-NPs增加了金屬硫蛋白基因的表達(dá)，該基因被認(rèn)為是金屬誘導(dǎo)毒性的生物標(biāo)志物?？傊?，ZnO-NPs可能通過氧化應(yīng)激誘導(dǎo)的細(xì)胞凋亡在人肺細(xì)胞中引起毒性。

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