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首頁> 美國衛(wèi)生研究院文獻>ISRN Toxicology >Influence of Mikania laevigata Extract over the Genotoxicity Induced by Alkylating Agents
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Influence of Mikania laevigata Extract over the Genotoxicity Induced by Alkylating Agents

機譯：薇甘菊提取物對烷基化劑誘導(dǎo)的遺傳毒性的影響

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Medicinal plants are still widely used worldwide; yet for some species, little or no information is available concerning their biological activity, specially their genotoxic and antimutagenic potential. Mikania laevigata (Asteraceae) is a native plant from South America, and its extracts are largely used to treat respiratory complaints. The aim of the present work was then to evaluate, in vivo, the potential biological activity of M. laevigata on the genotoxicity induced by methyl methanesulfonate (MMS) and cyclophosphamide (CP), using the comet assay. Male CF1 mice were divided into groups of 5-6 animals, received by gavage 0.1 mL/10 g body wt of water, Mikania laevigata extract (MLE), MMS, and CP. Results showed that treatment with 200 mg/kg of the MLE previously to MMS and CP administration, respectively, reduced the damage index (DI) in 52% and 60%, when compared to DI at 24 h. Pretreatment also reduced the damage frequency (DF) in 56% (MMS) and 58% (CP), compared to DF at 24 h. MLE administration has been shown to protect mouse DNA from damage induced by alkylating agents; this corroborates to the biological activities of M. laevigata and points towards the need of plant compounds isolation to proceed with further studies.
機譯：藥用植物在世界范圍內(nèi)仍被廣泛使用。但是對于某些物種，關(guān)于其生物活性，特別是其遺傳毒性和抗誘變潛力的信息很少或沒有。 Mikania laevigata（菊科）是一種來自南美的本地植物，其提取物主要用于治療呼吸系統(tǒng)不適。然后，本研究的目的是使用彗星試驗在體內(nèi)評估laevigata分枝桿菌對甲磺酸甲酯（MMS）和環(huán)磷酰胺（CP）誘導(dǎo)的遺傳毒性的潛在生物活性。將CF1雄性小鼠分為5-6只動物，分別灌胃0.1 mL / 10 g體重的水，Mikania laevigata提取物（MLE），MMS和CP。結(jié)果表明，與24 h時的DI相比，在MMS和CP給藥前分別以200μmg/ kg的MLE進行治療可使損傷指數(shù)（DI）降低52％和60％。與24小時時的DF相比，預(yù)處理還降低了56％（MMS）和58％（CP）的損傷頻率（DF）。已經(jīng)證明，MLE施用可保護小鼠DNA免受烷基化劑誘導(dǎo)的損害；這證實了長葉念珠菌的生物學(xué)活性，并指出需要分離植物化合物以進行進一步的研究。

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