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In Vitro Effects of Herbicides and Insecticides on Human Breast Cells

機(jī)譯：除草劑和殺蟲劑對人乳腺癌細(xì)胞的體外作用

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Numerous studies have indicated that the pesticides and herbicides used in agricultural processes in the United States and Europe may have detrimental effects upon human health. Many of these compounds have been indicated as potential endocrine and reproductive disruptors, although the studies have examined supraphysiological levels well above the US EPA safe levels for drinking water and have often examined these effects in “model” cell lines such as Chinese hamster ovary cells. We have now examined the cytotoxicity of more environmentally relevant concentrations of four herbicides, acetochlor, atrazine, cyanazine, and simazine, and two insecticides, chlorpyrifos and resmethrin, in three human breast cell lines. Interestingly, cytotoxicity was not observed in the estrogen-dependent MCF-7 mammary epithelial carcinoma cells; rather increases in cell viability were seen for some of the compounds at select concentrations. These results vary greatly from what was observed in the estrogen independent MDA-MB-231 breast cancer cells and the non-cancerous MCF-10A breast cells. This gives insight into how different tumors may respond to pesticide exposure and allows us to make more accurate conclusions about the potential cytotoxicity or, at times, stimulatory actions of these pesticides.
機(jī)譯：大量研究表明，美國和歐洲的農(nóng)業(yè)生產(chǎn)過程中使用的農(nóng)藥和除草劑可能會(huì)對人體健康產(chǎn)生不利影響。盡管研究已經(jīng)檢查了超生理水平遠(yuǎn)高于美國EPA飲用水安全水平，并且經(jīng)常檢查“模型”細(xì)胞系（例如中國倉鼠卵巢細(xì)胞）中的這些作用，但其中許多化合物已被指示為潛在的內(nèi)分泌和生殖干擾物?，F(xiàn)在，我們已經(jīng)研究了三種與人環(huán)境相關(guān)的濃度更高的環(huán)境相關(guān)濃度的四種除草劑乙草胺，at去津，氰嗪和西咪嗪，以及兩種殺蟲劑毒死rif和瑞思敏在三種人乳腺癌細(xì)胞系中的細(xì)胞毒性。有趣的是，在雌激素依賴性MCF-7乳腺上皮癌細(xì)胞中未觀察到細(xì)胞毒性。在某些濃度下，某些化合物的細(xì)胞活力有所提高。這些結(jié)果與在不依賴雌激素的MDA-MB-231乳腺癌細(xì)胞和非癌性MCF-10A乳腺癌細(xì)胞中觀察到的結(jié)果大不相同。這可以洞悉不同的腫瘤可能如何對農(nóng)藥暴露產(chǎn)生反應(yīng)，并使我們能夠?qū)@些農(nóng)藥的潛在細(xì)胞毒性或刺激作用做出更準(zhǔn)確的結(jié)論。

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