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Evaluation of Eye Irritation Potential of Aqueous Leaf Extract of Achyranthes aspera by In Vitro and In Vivo Method

機譯：體內和體外方法評價牛膝草葉提取物對眼睛的刺激潛力

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The present paper is an attempt to investigate the eye irritation potential of aqueous leaf extract of Achyranthes aspera by in vitro, Hen's Egg Chorioallantoic Membrane Test (HET-CAM) and in vivo acute eye irritation test in rabbits. The irritation score (IS) obtained after treatment of the extract on HET-CAM is 0.07 and that of in rabbits is 0.55, Which does not comes under either category 1 or 2 as per the harmonized integrated classification system. The aqueous extract of Achyranthes aspera showed no eye irritation properties both in vitro and in vivo methods when compared with negative control whereas positive controls showed eye irritation potential.

機譯：本文試圖通過體外，雞的卵絨膜尿囊膜試驗（HET-CAM）和體內急性兔眼刺激試驗來研究牛膝含水提取物的眼刺激潛力。在HET-CAM上處理提取物后獲得的刺激評分（IS）為0.07，而在兔子中為0.55，根據統(tǒng)一的綜合分類系統(tǒng)，刺激評分不屬于1類或2類。當與陰性對照相比時，牛膝的水提取物在體外和體內方法均未顯示出對眼睛的刺激性，而陽性對照則顯示了對眼睛的刺激性。

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期刊名稱 ISRN Toxicology
作者
Gajanan Rajpal Deshmukh; Kuntrapakam Hema Kumar; Poojari Venkata Suresh Reddy; Boddapati Srinivasa Rao; Chirumamilla Venkata Satish Kumar;
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作者單位

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年(卷),期 2012(2012),-1
年度 2012
頁碼 693489
總頁數 5
原文格式 PDF
正文語種
中圖分類毒物學（毒理學）;
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1. Evaluation of Eye Irritation Potential of Aqueous Leaf Extract ofAchyranthes asperabyIn VitroandIn VivoMethod [J] . GajananRajpal Deshmukh, KuntrapakamHema Kumar, Poojari VenkataSuresh Reddy, International Scholarly Research Notices . 2012,第4期

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2. Evaluation of anti-obesity potential of aqueous extract of Achyranthes aspera Linn. in high fat diet induced obese rats [J] . Kumaraswamy Athesh, Rangaraju Sivasubramanian, Gnanasekaran Jothi, Clinical Phytoscience . 2020,第1期

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3. EVALUATION OF IN VITRO ANTIOXIDANT POTENTIAL OF ETHANOLIC EXTRACT FROM THE LEAVES OF ACHYRANTHES ASPERA [J] . ARUNACHALAM KUMAR, SUCHETHA KUMARI N, DIVYA BHARGAVAN Asian Journal of Pharmaceutical and Clinical Research . 2012,第3期

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5. Assessment of skin absorption and irritation potential of arachidonic acid and glyceryl arachidonate using in vitro diffusion cell techniques. [D] . Eppler, Angela Rae. 2005

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6. Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods [O] . Els Adriaens, Jo?o Barroso, Chantra Eskes, -1

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7. Evaluation of Eye Irritation Potential of Aqueous Leaf Extract of Achyranthes aspera by In Vitro and In Vivo Method [O] . Gajanan Rajpal Deshmukh, Kuntrapakam Hema Kumar, Poojari Venkata Suresh Reddy, 2012

機譯：體外和體內方法評價achyranthes achyshah achyshys水葉片提取物的刺激潛力

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Evaluation of Eye Irritation Potential of Aqueous Leaf Extract of Achyranthes aspera by In Vitro and In Vivo Method

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