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首頁> 美國衛(wèi)生研究院文獻(xiàn)>Biochemistry Insights >Combined Efficacy of Gallic Acid and MiADMSA with Limited Beneficial Effects Over MiADMSA Against Arsenic-induced Oxidative Stress in Mouse
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Combined Efficacy of Gallic Acid and MiADMSA with Limited Beneficial Effects Over MiADMSA Against Arsenic-induced Oxidative Stress in Mouse

機(jī)譯：沒食子酸和MiADMSA的聯(lián)合功效對MiADMSA的抗砷誘導(dǎo)的小鼠氧化應(yīng)激作用有限

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Gallic acid is an organic acid known for its antioxidant and anticancer properties. The present study is focused on evaluating the role of gallic acid in providing better therapeutic outcomes against arsenic-induced toxicity. Animals pre-exposed to arsenic were treated with monoisoamyl meso-2,3-dimercaptosuccinic acid (MiADMSA), a new chelating drug, alone and in combination with gallic acid, consecutively for 10 days. The study suggests that (1) gallic acid in presence of MiADMSA is only moderately beneficial against arsenic, (2) monotherapy with gallic acid is more effective than in combination with MiADMSA after arsenic exposure in reducing oxidative injury, and (3) MiADMSA monotherapy as reported previously provides significant therapeutic efficacy against arsenic. Thus, based on the present results, we conclude that gallic acid is effective against arsenic-induced oxidative stress but provides limited additional beneficial effects when administered in combination with MiADMSA. We still recommend that lower doses of gallic acid be evaluated both individually and in combination with MiADMSA, as it might not exhibit the shortcomings we observed with higher doses in this study.
機(jī)譯：沒食子酸是一種有機(jī)酸，以其抗氧化和抗癌特性而聞名。本研究的重點(diǎn)是評估沒食子酸在提供更好的針對砷引起的毒性的治療效果方面的作用。預(yù)先將砷暴露的動物單獨(dú)和與沒食子酸組合用新的螯合藥物單異戊基間消旋2,3-二巰基琥珀酸（MiADMSA）連續(xù)治療10天。研究表明（1）含MiADMSA的沒食子酸僅對砷有中等程度的益處；（2）沒食子酸加砷后的單藥治療比聯(lián)合MiADMSA減少氧化損傷更有效；（3）含MiADMSA的單藥治療先前報道的抗砷劑具有顯著的治療功效。因此，基于目前的結(jié)果，我們得出結(jié)論，沒食子酸可有效抵抗砷誘導(dǎo)的氧化應(yīng)激，但與MiADMSA聯(lián)合使用時，可提供有限的額外有益作用。我們?nèi)匀唤ㄗh單獨(dú)或與MiADMSA聯(lián)合評估較低劑量的沒食子酸，因?yàn)樗赡懿粫憩F(xiàn)出我們在較高劑量下觀察到的缺點(diǎn)。

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