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首頁(yè)> 美國(guó)衛(wèi)生研究院文獻(xiàn)>Bacteriophage >Isolation and characterization of a novel phage lysin active against Paenibacillus larvae a honeybee pathogen
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Isolation and characterization of a novel phage lysin active against Paenibacillus larvae a honeybee pathogen

機(jī)譯：新型抗噬菌體噬菌體溶素的分離和鑒定

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Paenibacillus larvae is the causative agent of American foulbrood (AFB) disease which affects early larval stages during honeybee development. Due to its virulence, transmissibility, capacity to develop antibiotic resistance, and the inherent resilience of its endospores, Paenibacillus larvae is extremely difficult to eradicate from infected hives which often must be burned. AFB contributes to the worldwide decline of honeybee populations, which are crucial for pollination and the food supply. We have isolated a novel bacteriophage lysin, PlyPalA, from the genome of a novel Paenibacillus larvae bacteriophage originally extracted from an environmental sample. PlyPalA has an N-terminal N-acetylmuramoyl-L-alanine amidase catalytic domain and possesses lytic activity against infectious strains of Paenibacillus larvae without harming commensal bacteria known to compose the honeybee larval microbiota. A single dose of PlyPalA rescued 75% of larvae infected with endospores, showing that it represents a powerful tool for future treatment of AFB. This represents the first time that lysins have been tested for therapeutic use in invertebrates.
機(jī)譯：桿狀芽孢桿菌幼蟲(chóng)是美國(guó)臭蠅（AFB）病的病原體，它會(huì)影響蜜蜂發(fā)育期間的幼蟲(chóng)早期階段。由于其毒力，可傳播性，產(chǎn)生抗生素抗性的能力以及其內(nèi)生孢子的固有彈性，極難從通常必須燃燒的被感染的蜂箱中根除幼芽孢桿菌幼蟲(chóng)。 AFB助長(zhǎng)了全球蜜蜂數(shù)量的下降，這對(duì)授粉和食物供應(yīng)至關(guān)重要。我們從最初從環(huán)境樣品中提取的新型Paenibacillus幼蟲(chóng)噬菌體的基因組中分離了一種新型噬菌體溶素PlyPalA。 PlyPalA具有一個(gè)N端N-乙酰基村?；?L-丙氨酸酰胺酶催化結(jié)構(gòu)域，并具有對(duì)付Paenibacillus幼蟲(chóng)感染株的裂解活性，而不會(huì)損害已知構(gòu)成蜜蜂幼蟲(chóng)微生物群的共生細(xì)菌。單劑量的PlyPalA可以挽救75％的被內(nèi)生孢子感染的幼蟲(chóng)，這表明它是將來(lái)治療AFB的有力工具。這代表溶素首次被測(cè)試用于無(wú)脊椎動(dòng)物的治療用途。

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