Bioinformatics as a first-line approach for understanding bacteriophage transcription

機(jī)譯：生物信息學(xué)是理解噬菌體轉(zhuǎn)錄的第一線方法

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摘要

Current approach to understanding bacteriophage transcription strategies during infection includes a combination of experimental and bioinformatics approaches, which is often time and resource consuming. Given the exponentially growing number of sequenced bacteriophage genomes, it becomes sensible asking to what extent one can understand bacteriophage transcription by using bioinformatics methods alone. We here argue that a suitable choice of computational methods may provide a highly efficient first-line approach for underst-anding bacteriophage transcription.

機(jī)譯：當(dāng)前了解感染過程中噬菌體轉(zhuǎn)錄策略的方法包括實(shí)驗(yàn)方法和生物信息學(xué)方法的組合，這通常是時(shí)間和資源的消耗。鑒于已測序的噬菌體基因組數(shù)目呈指數(shù)增長，因此明智地詢問人們僅使用生物信息學(xué)方法就能在多大程度上理解噬菌體的轉(zhuǎn)錄。我們在這里辯稱，計(jì)算方法的適當(dāng)選擇可能為了解噬菌體轉(zhuǎn)錄提供一種高效的一線方法。

著錄項(xiàng)

期刊名稱 Bacteriophage
作者
Jelena Guzina; Marko Djordjevic;
展開▼
作者單位

展開▼
年(卷),期 2015(5),3
年度 2015
頁碼 e1062588
總頁數(shù) 5
原文格式 PDF
正文語種
中圖分類微生物學(xué);
關(guān)鍵詞
bacteriophage transcription bioinformatics analysis computational genomics genome analysis promoter predictions transcription start-site prediction;

機(jī)譯：噬菌體轉(zhuǎn)錄;生物信息學(xué)分析;計(jì)算基因組學(xué);基因組分析;啟動(dòng)子預(yù)測;轉(zhuǎn)錄起始位點(diǎn)預(yù)測;

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專利

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4. A Bioinformatics Approach to the Analysis of Combinatorial Transcriptional Regulation (Abstract) [C] . Sarita Nair, Praveen Chakravarthula, Rajanikanth Vadigepalli International Symposium on Runaway Reactions, Pressure Relief Design and Effluent Handling American Institute of Chemical Engineers/American Chemical Society Management Conference . 2005

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5. Biophysics and bioinformatics of transcription regulation in bacteria and bacteriophages. [D] . Djordjevic, Marko. 2005

機(jī)譯：細(xì)菌和噬菌體中轉(zhuǎn)錄調(diào)控的生物物理學(xué)和生物信息學(xué)。
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Bioinformatics as a first-line approach for understanding bacteriophage transcription

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