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Schistosomiasis-associated kidney disease: A review

機(jī)譯：血吸蟲病相關(guān)的腎臟疾?。壕C述

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摘要

Schistosomiasis is a parasitic disease caused by organisms from the genus Schistosoma. The disease is endemic in tropical areas, where there are currently millions of people living in areas with transmission risk. Schistosomiasis-associated kidney disease is not frequently described in literature. The disease has a chronic evolution, with variable severity. Glomerulonephritis is described in 10-12% in autopsy studies. Proteinuria is reported in 20% of patients with S. mansoni infection. Schistosomal glomerulopathy generally occur in young patients, male, with hepato-splenomegaly. The glomerular lesion in schistosomiasis has an immunological nature. Antigens from the parasite seem to be related to glomerulopathy and have been found in the sera of humans and animals infected by the S. mansoni. Vesical involvement is common in the infection by S. haematobium, a parasitic disease prevalent in African countries. In the S. haematobium infection, hematuria and dysuria can be observed due to inflammation and ulceration in the bladder mucosa, generaly occuring 3 to 4 months after primary infection. Specific antiparasitic treatment is indicated to all patients infected by Schistosoma. There are 2 drugs available for treatment, praziquantel and oxamniquine. We revise the general aspects of the disease and describe the features of renal involvement in schistosomiasis.
機(jī)譯：血吸蟲病是由血吸蟲屬的生物引起的寄生蟲病。該病是熱帶地區(qū)的地方病，目前有數(shù)百萬(wàn)人生活在具有傳播風(fēng)險(xiǎn)的地區(qū)。文獻(xiàn)中不經(jīng)常描述血吸蟲病相關(guān)的腎臟疾病。該疾病具有慢性演變，嚴(yán)重程度不同。在尸檢研究中，腎小球腎炎占10-12％。據(jù)報(bào)道，曼氏鏈球菌感染患者中有20％患有蛋白尿。血吸蟲性腎小球病變通常發(fā)生在年輕的男性，肝脾腫大。血吸蟲病的腎小球病變具有免疫學(xué)性質(zhì)。來(lái)自該寄生蟲的抗原似乎與腎小球病有關(guān)，并已在曼氏沙門氏菌感染的人和動(dòng)物的血清中發(fā)現(xiàn)。在非洲國(guó)家普遍存在的一種寄生蟲病-沙門氏菌感染中，通常會(huì)涉及到膀胱感染。在S. haematobium感染中，由于膀胱粘膜的炎癥和潰瘍，可觀察到血尿和排尿困難，通常發(fā)生在初次感染后3至4個(gè)月。對(duì)于所有被血吸蟲感染的患者，都需要進(jìn)行特殊的抗寄生蟲治療。有2種藥物可供治療：吡喹酮和奧沙尼喹。我們修訂了疾病的一般方面，并描述了血吸蟲病中腎臟受累的特征。

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