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首頁> 美國衛(wèi)生研究院文獻>Endocrinology >The Nuclear Receptor Corepressor Has Organizational Effects within the Developing Amygdala on Juvenile Social Play and Anxiety-Like Behavior
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The Nuclear Receptor Corepressor Has Organizational Effects within the Developing Amygdala on Juvenile Social Play and Anxiety-Like Behavior

機譯：核受體共抑制因子在杏仁核發(fā)育過程中對青少年社交活動和焦慮行為具有組織作用

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Nuclear receptor function on DNA is regulated by the balanced recruitment of coregulatory complexes. Recruited proteins that increase gene expression are called coactivators, and those that decrease gene expression are called corepressors. Little is known about the role of corepressors, such as nuclear receptor corepressor (NCoR), on the organization of behavior. We used real-time PCR to show that NCoR mRNA levels are sexually dimorphic, that females express higher levels of NCoR mRNA within the developing amygdala and hypothalamus, and that NCoR mRNA levels are reduced by estradiol treatment. To investigate the functional role of NCoR on juvenile social behavior, we infused small interfering RNA targeted against NCoR within the developing rat amygdala and assessed the enduring impact on juvenile social play behavior, sociability, and anxiety-like behavior. As expected, control males exhibited higher levels of juvenile social play than control females. Reducing NCoR expression during development further increased juvenile play in males only. Interestingly, decreased NCoR expression within the developing amygdala had lasting effects on increasing juvenile anxiety-like behavior in males and females. These data suggest that the corepressor NCoR functions to blunt sex differences in juvenile play behavior, a sexually dimorphic and hormone-dependent behavior, and appears critical for appropriate anxiety-like behavior in juvenile males and females.
機譯：DNA上的核受體功能受調(diào)節(jié)性復合物平衡募集的調(diào)節(jié)。募集的增加基因表達的蛋白質(zhì)被稱為共激活因子，而那些減少基因表達的蛋白質(zhì)被稱為共加壓因子。關(guān)于諸如心臟核受體的核心受體（NCoR）的核心受體在行為組織中的作用還知之甚少。我們使用實時PCR來顯示NCoR mRNA水平具有性別雙態(tài)性，雌性在發(fā)育中的杏仁核和下丘腦中表達較高水平的NCoR mRNA，并且雌二醇治療可降低NCoR mRNA水平。為了研究NCoR在青少年社交行為中的功能作用，我們在發(fā)育中的大鼠杏仁核內(nèi)注入了針對NCoR的小干擾RNA，并評估了其對青少年社交行為，社交性和焦慮樣行為的持久影響。不出所料，對照男性比對照女性表現(xiàn)出更高水平的青少年社交活動。在發(fā)育過程中減少NCoR的表達僅進一步增加了男性的少年游戲。有趣的是，發(fā)育中的杏仁核內(nèi)NCoR表達的降低對男性和女性的青少年焦慮樣行為具有持久的影響。這些數(shù)據(jù)表明，在青少年游戲行為，性二態(tài)性和激素依賴性行為中，鎮(zhèn)靜劑NCoR的作用是鈍化性別差異，并且對于少年男性和女性的適當焦慮樣行為顯得至關(guān)重要。

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