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首頁> 美國衛(wèi)生研究院文獻>Experimental and Therapeutic Medicine >Effect of mild hypothermia on expression of inflammatory factors in surrounding tissue after minimally invasive hematoma evacuation in the treatment of hypertensive intracerebral hemorrhage
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Effect of mild hypothermia on expression of inflammatory factors in surrounding tissue after minimally invasive hematoma evacuation in the treatment of hypertensive intracerebral hemorrhage

機譯：亞低溫對微創(chuàng)血腫撤除后高血壓腦出血患者周圍組織炎癥因子表達的影響

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Mild hypothermia combined with minimally invasive hematoma evacuation was evaluated in the treatment of hypertensive intracerebral hemorrhage to reduce inflammatory response of brain tissue around hematoma and ameliorate brain function, and to investigate its safety, effectiveness and feasibility. A total of 206 patients with acute spontaneous hypertensive intracerebral hemorrhage were collected clinically and randomly divided into minimally invasive hematoma evacuation group (group A) and mild hypothermia combined with minimally invasive hematoma evacuation (group B). The National Institutes of Health Stroke Scale (NIHSS) score was used before and after treatment. Group A was treated with minimally invasive intracranial hematoma evacuation using intracranial hematoma grinding puncture needle while group B received whole body water circulation type cooling blanket plus local cerebral mild hypothermia therapy with ice cap on the basis of minimally invasive surgery. Patients brain tissue fragments around hematoma taken out with rinsing during operation and at postoperative 1, 3 and 7 days were investigated. The contents of tumor necrosis factor-α (TNF-α) in serum at postoperative 1, 3 and 7 days were evaluated by enzyme-linked immunosorbent assay (ELISA). For the degree of nerve function defect of patients in the two groups, NIHSS score was lower in group B than that in group A at days 3 and 7, and the differences were statistically significant (P<0.05). The serum TNF-α content and expression of nuclear factor-κB (NF-κB) in brain tissue around hematoma reached the peak on the 3rd day. The TNF-α content and NF-κB expression were lower in group B than those in group A at each time-point (P<0.05). Mild hypothermia combined with minimally invasive hematoma evacuation can reduce the damage of hematoma to the surrounding brain tissue, effectively alleviate inflammatory response and decrease brain tissue injury, thus ameliorating brain function.
機譯：評價輕度低溫并結合微創(chuàng)血腫清除術治療高血壓腦出血，以減少血腫周圍腦組織的炎癥反應并改善腦功能，并研究其安全性，有效性和可行性。臨床共收集206例急性自發(fā)性高血壓腦出血患者，隨機分為微創(chuàng)血腫清除術組（A組）和輕度體溫過低伴微創(chuàng)血腫清除術（B組）。美國國立衛(wèi)生研究院卒中量表（NIHSS）評分用于治療前后。 A組采用顱內(nèi)血腫磨針穿刺行顱內(nèi)血腫微創(chuàng)治療，B組在微創(chuàng)手術的基礎上接受全身水循環(huán)式降溫毯加冰帽局部腦輕度低溫治療。研究了在手術期間以及術后1、3和7天沖洗后取出的血腫周圍的腦組織碎片。通過酶聯(lián)免疫吸附試驗（ELISA）評估術后1、3和7天時血清中腫瘤壞死因子-α（TNF-α）的含量。就兩組患者的神經(jīng)功能缺損程度而言，在第3天和第7天，B組的NIHSS評分低于A組，差異有統(tǒng)計學意義（P <0.05）。第3天血腫周圍腦組織中血清TNF-α含量和核因子-κB（NF-κB）表達達到高峰。 B組各時間點的TNF-α含量和NF-κB表達均低于A組（P <0.05）。輕度低溫加上微創(chuàng)血腫清除術可以減少血腫對周圍腦組織的損害，有效減輕炎癥反應并減少腦組織損傷，從而改善腦功能。

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