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首頁> 美國衛(wèi)生研究院文獻>Advanced Journal of Emergency Medicine >Silymarin as a Promising Potential Therapeutic Agent for Treatment of Patients with Paraquat Poisoning: An Issue that Merits Further Research
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Silymarin as a Promising Potential Therapeutic Agent for Treatment of Patients with Paraquat Poisoning: An Issue that Merits Further Research

機譯：水飛薊素作為百草枯中毒患者的潛在治療劑：值得進一步研究的問題

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Having an extremely toxic compound for humans and most animals, paraquat (PQ) is known as one of the most frequently used herbicides. Accordingly, PQ poisoning has been recognized as a serious medical problem across the world, with a severe case fatality rate (CFR) ( , ). In this respect; accidental or intentional ingestion of PQ, even in a small amount, can be significantly associated with poor clinical prognosis and increased mortality. Moreover; inherent toxicity of PQ, absence of specific antidotes, as well as lack of effective treatments have been principally attributed to high fatality of PQ poisoning. Once PQ is ingested, it can be absorbed through skin and the digestive and respiratory system and often progresses to multi-organ failure, particularly the lungs as the main target. In this respect, PQ accumulates predominantly in the lungs and can lead to lung fibrosis, pneumonitis, and consequently respiratory failure and death ( , ). Given the nonexistence of specific and widely accepted guidelines for treatment of PQ poisoning, a range of conservative therapeutic modalities have been proposed and administered by clinicians to moderate PQ absorption and to prevent organ failure in these patients. In spite of this, PQ-induced mortality rate is high and disappointing ( , ).
機譯：百草枯（PQ）具有對人類和大多數(shù)動物極具毒性的化合物，是最常用的除草劑之一。因此，在世界范圍內(nèi)，PQ中毒已被認為是嚴重的醫(yī)學(xué)問題，病死率很高（CFR）（）。在這方面；意外或有意攝入PQ，即使少量也可能與不良的臨床預(yù)后和增加的死亡率密切相關(guān)。此外; PQ的固有毒性，缺乏特定的解毒劑以及缺乏有效的治療方法，主要歸因于PQ中毒的高死亡率。攝入PQ后，它可以通過皮膚，消化系統(tǒng)和呼吸系統(tǒng)吸收，并經(jīng)常發(fā)展為多器官功能衰竭，尤其是以肺為主要目標。在這方面，PQ主要在肺中積累，可導(dǎo)致肺纖維化，肺炎，并因此導(dǎo)致呼吸衰竭和死亡（）?？紤]到不存在治療PQ中毒的具體且廣為接受的指南，臨床醫(yī)生已提出并實施了一系列保守的治療方式，以緩和PQ的吸收并預(yù)防這些患者的器官衰竭。盡管如此，PQ引起的死亡率很高，令人失望（）。

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