国产bbaaaaa片,成年美女黄网站色视频免费,成年黄大片,а天堂中文最新一区二区三区,成人精品视频一区二区三区尤物

首頁(yè)> 美國(guó)衛(wèi)生研究院文獻(xiàn)>Future Microbiology >Causes of impaired oral vaccine efficacy in developing countries
【2h】

Causes of impaired oral vaccine efficacy in developing countries

機(jī)譯:發(fā)展中國(guó)家口服疫苗功效受損的原因

代理獲取
本網(wǎng)站僅為用戶提供外文OA文獻(xiàn)查詢和代理獲取服務(wù),本網(wǎng)站沒(méi)有原文。下單后我們將采用程序或人工為您竭誠(chéng)獲取高質(zhì)量的原文,但由于OA文獻(xiàn)來(lái)源多樣且變更頻繁,仍可能出現(xiàn)獲取不到、文獻(xiàn)不完整或與標(biāo)題不符等情況,如果獲取不到我們將提供退款服務(wù)。請(qǐng)知悉。

摘要

Oral vaccines are less immunogenic when given to infants in low-income compared with high-income countries, limiting their potential public health impact. Here, we review factors that might contribute to this phenomenon, including transplacental antibodies, breastfeeding, histo blood group antigens, enteric pathogens, malnutrition, microbiota dysbiosis and environmental enteropathy. We highlight several clear risk factors for vaccine failure, such as the inhibitory effect of enteroviruses on oral poliovirus vaccine. We also highlight the ambiguous and at times contradictory nature of the available evidence, which undoubtedly reflects the complex and interconnected nature of the factors involved. Mechanisms responsible for diminished immunogenicity may be specific to each oral vaccine. Interventions aiming to improve vaccine performance may need to reflect the diversity of these mechanisms.
機(jī)譯:與高收入國(guó)家相比,低收入嬰兒口服疫苗的免疫原性較低,限制了其潛在的公共衛(wèi)生影響。在這里,我們回顧了可能導(dǎo)致這種現(xiàn)象的因素,包括胎盤抗體,母乳喂養(yǎng),組織血型抗原,腸道病原體,營(yíng)養(yǎng)不良,微生物群營(yíng)養(yǎng)不良和環(huán)境性腸病。我們著重指出疫苗失敗的幾個(gè)明確風(fēng)險(xiǎn)因素,例如腸病毒對(duì)口服脊髓灰質(zhì)炎病毒疫苗的抑制作用。我們還強(qiáng)調(diào)了現(xiàn)有證據(jù)的模棱兩可,有時(shí)相互矛盾的性質(zhì),這無(wú)疑反映了所涉因素的復(fù)雜性和相互聯(lián)系的性質(zhì)。導(dǎo)致免疫原性降低的機(jī)制可能是每種口服疫苗所特有的。旨在提高疫苗性能的干預(yù)措施可能需要反映這些機(jī)制的多樣性。

著錄項(xiàng)

相似文獻(xiàn)

  • 外文文獻(xiàn)
  • 中文文獻(xiàn)
  • 專利
代理獲取

客服郵箱:kefu@zhangqiaokeyan.com

京公網(wǎng)安備:11010802029741號(hào) ICP備案號(hào):京ICP備15016152號(hào)-6 六維聯(lián)合信息科技 (北京) 有限公司?版權(quán)所有
  • 客服微信

  • 服務(wù)號(hào)