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Influence of the Introduced Chitin Nanofibrils on Biomedical Properties of Chitosan-Based Materials

機譯：幾丁質納米纖維的引入對殼聚糖基材料生物醫(yī)學性能的影響

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Hemorrhage occurring during and after surgery still remains one of the biggest problems in medicine. Although a large number of hemostatic products have been created, there is no universal preparation; thus, the development of new materials is an urgent task. The aim of this research is to increase hemostatic properties of chitosan by introducing chitin nanofibrils (ChNF). The blood absorbance by ChNF-containing chitosan sponges and time-until-arrest of bleeding were studied. Non-woven materials containing 0.5% of ChNF and materials without chitin were obtained. The studies of ζ-potential showed that the material containing 0.5% ChNF had relatively a high positive charge, but efficiencies of both materials for hemorrhage arrest were comparable to those of commercial hemostatic products (Surgicel and TachoComb). To investigate the interaction between the materials and living organism, histological studies and optical microscopy studies were conducted after implantation of fibers. Despite bioinertness of fibers, implantation of non-woven materials led to formation of significant granulomas.
機譯：手術期間和之后發(fā)生的出血仍然是醫(yī)學上最大的問題之一。盡管已經(jīng)生產(chǎn)出大量止血產(chǎn)品，但是還沒有通用的制劑。因此，開發(fā)新材料是當務之急。這項研究的目的是通過引入幾丁質納米纖維（ChNF）來提高殼聚糖的止血性能。研究了含ChNF的殼聚糖海綿對血液的吸收和直到出血的時間。獲得了含有0.5％ChNF的非織造材料和沒有甲殼質的材料。 ζ電位研究表明，含有0.5％ChNF的材料具有較高的正電荷，但是兩種材料的止血效率均與市售止血產(chǎn)品（Surgicel和TachoComb）相當。為了研究材料與活生物體之間的相互作用，在植入纖維后進行了組織學和光學顯微鏡研究。盡管纖維具有生物惰性，但非織造材料的植入導致形成明顯的肉芽腫。

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