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Label-Free Split Aptamer Sensor for Femtomolar Detection of Dopamine by Means of Flexible Organic Electrochemical Transistors

機(jī)譯：借助柔性有機(jī)電化學(xué)晶體管在飛克分子中檢測(cè)多巴胺的無標(biāo)記分離式適體傳感器

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The detection of chemical messenger molecules, such as neurotransmitters in nervous systems, demands high sensitivity to measure small variations, selectivity to eliminate interferences from analogues, and compliant devices to be minimally invasive to soft tissue. Here, an organic electrochemical transistor (OECT) embedded in a flexible polyimide substrate is utilized as transducer to realize a highly sensitive dopamine aptasensor. A split aptamer is tethered to a gold gate electrode and the analyte binding can be detected optionally either via an amperometric or a potentiometric transducer principle. The amperometric sensor can detect dopamine with a limit of detection of 1 μM, while the novel flexible OECT-based biosensor exhibits an ultralow detection limit down to the concentration of 0.5 fM, which is lower than all previously reported electrochemical sensors for dopamine detection. The low detection limit can be attributed to the intrinsic amplification properties of OECTs. Furthermore, a significant response to dopamine inputs among interfering analogues hallmarks the selective detection capabilities of this sensor. The high sensitivity and selectivity, as well as the flexible properties of the OECT-based aptasensor, are promising features for their integration in neuronal probes for the in vitro or in vivo detection of neurochemical signals.
機(jī)譯：對(duì)化學(xué)信使分子（例如神經(jīng)系統(tǒng)中的神經(jīng)遞質(zhì)）的檢測(cè)要求高靈敏度以測(cè)量微小變化，選擇性以消除類似物的干擾，以及對(duì)軟組織的侵入性最小的順應(yīng)性設(shè)備。在此，嵌入在柔性聚酰亞胺襯底中的有機(jī)電化學(xué)晶體管（OECT）被用作換能器，以實(shí)現(xiàn)高靈敏度的多巴胺適體傳感器。分離的適體束縛在金柵電極上，可以通過安培或電位傳感器原理選擇性地檢測(cè)分析物的結(jié)合。安培傳感器可以檢測(cè)到多巴胺，檢測(cè)極限為1μM，而新型基于OECT的柔性生物傳感器則顯示出低至0.5 fM的超低檢測(cè)極限，低于所有先前報(bào)道的用于多巴胺檢測(cè)的電化學(xué)傳感器。低檢測(cè)限可歸因于OECT的固有擴(kuò)增特性。此外，干擾類似物之間對(duì)多巴胺輸入的顯著反應(yīng)標(biāo)志著該傳感器的選擇性檢測(cè)能力?；贠ECT的適體傳感器的高靈敏度和選擇性以及靈活的特性，對(duì)于將它們整合到神經(jīng)元探針中進(jìn)行體外或體內(nèi)神經(jīng)化學(xué)信號(hào)檢測(cè)而言，是很有前途的功能。

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