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首頁(yè)> 美國(guó)衛(wèi)生研究院文獻(xiàn)>American Journal of Stem Cells >Autologous adipose-derived stromal vascular fraction (SVF) in scar treatment among patients with keloids and hypertrophic scars: a systematic review and meta-analysis of current practices and outcomes
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Autologous adipose-derived stromal vascular fraction (SVF) in scar treatment among patients with keloids and hypertrophic scars: a systematic review and meta-analysis of current practices and outcomes

機(jī)譯：瘢痕疙瘩和增生性瘢痕患者瘢痕治療中的自體脂肪衍生基質(zhì)血管分?jǐn)?shù) （SVF）：當(dāng)前實(shí)踐和結(jié)果的系統(tǒng)評(píng)價(jià)和薈萃分析

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Background: Keloids and hypertrophic scars are some of the most common skin conditions globally, associated with poor treatment response and high recurrence rates. Autologous adipose-derived stromal vascular fraction (SVF) is increasingly recognized as an emerging therapy albeit limited literature on its outcome in scar treatment. This review aimed to describe the current practices and outcomes of adipose-derived stromal Vascular Fraction in scar treatment. Methods: This systematic review assessed articles describing the use of SVF in scar treatment published between 2000 and 2023. Article searches of Medline/PubMed, Cochrane Library, and Embase databases using Mesh terms and the Boolean operators (“AND”, “OR”) by two independent researchers were done whilst following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Clinical studies assessing SVF in scar treatment with a primary outcome measure being an improvement in scar characteristics including the thickness, scar assessment scores were included. Results: Among the 1425 studies identified in the search, 20 studies met the inclusion criteria with a total of 493 patients included. Eight of these were clinical trials with the rest being observational studies. Follow-up ranged from 3 months to 24 months. In all studies, there was an improvement in scar characteristics following single-dose treatment with SVF or its equivalent. All studies reported SVF to be safe. Conclusion: The review found that autologous adipose-derived SVF is a clinically effective therapy for keloids and scar treatment.
機(jī)譯：背景： 瘢痕疙瘩和增生性疤痕是全球最常見(jiàn)的皮膚病之一，與治療反應(yīng)不佳和高復(fù)發(fā)率有關(guān)。自體脂肪來(lái)源的基質(zhì)血管分?jǐn)?shù) （SVF） 越來(lái)越被認(rèn)為是一種新興療法，盡管關(guān)于其在疤痕治療中結(jié)果的文獻(xiàn)有限。本綜述旨在描述脂肪來(lái)源的基質(zhì)血管分?jǐn)?shù)在疤痕治療中的當(dāng)前做法和結(jié)果。方法： 本系統(tǒng)評(píng)價(jià)評(píng)估了 2000 年至 2023 年間發(fā)表的描述 SVF 在疤痕治療中使用的文章。兩名獨(dú)立研究人員使用網(wǎng)狀詞和布爾運(yùn)算符（“AND”、“OR”）對(duì) Medline/PubMed、Cochrane Library 和 Embase 數(shù)據(jù)庫(kù)進(jìn)行文章檢索，同時(shí)遵循系統(tǒng)評(píng)價(jià)和薈萃分析的首選報(bào)告項(xiàng)目 （PRISMA） 指南。評(píng)估 SVF 在疤痕治療中的臨床研究，主要結(jié)局指標(biāo)是疤痕特征的改善，包括厚度、疤痕評(píng)估評(píng)分。結(jié)果： 在檢索確定的 1425 項(xiàng)研究中，20 項(xiàng)研究符合納入標(biāo)準(zhǔn)，共納入 493 名患者。其中 8 項(xiàng)是臨床試驗(yàn)，其余是觀察性研究。隨訪時(shí)間從 3 個(gè)月到 24 個(gè)月不等。在所有研究中，使用 SVF 或其等效物進(jìn)行單劑量治療后，疤痕特征有所改善。所有研究都報(bào)告 SVF 是安全的。結(jié)論： 本綜述發(fā)現(xiàn)，自體脂肪來(lái)源的 SVF 是一種臨床有效的瘢痕疙瘩和疤痕治療療法。

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