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Exploring the application of stem cell technology in treating sensorineural hearing loss

機(jī)譯：探索干細(xì)胞技術(shù)在治療感音神經(jīng)性聽力損失中的應(yīng)用

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Sensorineural deafness mainly occurs due to damage to hair cells, and advances in stem cell technology, especially the application of induced pluripotent stem cells (iPSCs) and adult stem cells, provides new possibilities for hair cell regeneration. This review describes the basic knowledge of stem cells and their important applications in regenerative medicine, as well as recent progress in stem cell research in the field of hair cell regeneration, especially the induced differentiation of hair-like cells. At the same time, we also point out the challenges facing current research, including differentiation efficiency, cell stability issues, and treatment safety and long-term efficacy considerations. Finally, we look forward to the direction of future research, and emphasize the importance of the cell differentiation mechanism, simulation of the inner ear microenvironment, safety assessment, and personalized treatment strategies. In conclusion, despite many challenges, stem cell technology has shown great potential in the field of hearing research and is expected to bring revolutionary treatment options for patients with sensorineural hearing loss in the future.
機(jī)譯：感音神經(jīng)性耳聾主要是由于毛細(xì)胞受損而發(fā)生的，干細(xì)胞技術(shù)的進(jìn)步，特別是誘導(dǎo)多能干細(xì)胞 （iPSC） 和成體干細(xì)胞的應(yīng)用，為毛細(xì)胞再生提供了新的可能性。本文綜述了干細(xì)胞的基本知識(shí)及其在再生醫(yī)學(xué)中的重要應(yīng)用，以及干細(xì)胞在毛細(xì)胞再生領(lǐng)域的研究進(jìn)展，特別是毛發(fā)樣細(xì)胞的誘導(dǎo)分化。同時(shí)，我們還指出了當(dāng)前研究面臨的挑戰(zhàn)，包括分化效率、細(xì)胞穩(wěn)定性問題以及治療安全性和長期療效考慮。最后，我們期待未來的研究方向，并強(qiáng)調(diào)細(xì)胞分化機(jī)制、內(nèi)耳微環(huán)境模擬、安全性評(píng)估和個(gè)性化治療策略的重要性?？傊?，盡管存在許多挑戰(zhàn)，但干細(xì)胞技術(shù)在聽力研究領(lǐng)域顯示出巨大的潛力，有望在未來為感音神經(jīng)性聽力損失患者帶來革命性的治療選擇。

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