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Inhibition of Bacterial Quorum Sensing by Extracts from Aquatic Fungi: First Report from Marine Endophytes

機(jī)譯：水生真菌提取物抑制細(xì)菌群體感應(yīng)：海洋內(nèi)生菌的首次報(bào)道

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In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out for their potent activity at concentrations from 500 to 50 μg mL−1. The molecular characterization, based on the internal transcribed spacer (ITS) region sequences (ITS1, 5.8S and ITS2) between the rRNA of 18S and 28S, identified these strains as belonging to four genera: Sarocladium (LAEE06), Fusarium (LAEE13), Epicoccum (LAEE14), and Khuskia (LAEE21). Interestingly, three came from coral species and two of them came from the same organism, the coral Diploria strigosa. Metabolic profiles obtained by Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) suggest that a combination of fungal secondary metabolites and fatty acids could be the responsible for the observed activities. The LC-HRMS analysis also revealed the presence of potentially new secondary metabolites. This is, to the best of our knowledge, the first report of QS inhibition by marine endophytic fungi.
機(jī)譯：在我們尋找群體感應(yīng)（QS）破壞分子的過程中，從珊瑚生物（內(nèi)生植物），鹽湖和紅樹林根際中回收了75種真菌分離物。在紫桿菌CVO26中評估了它們的QS抑制活性。四種內(nèi)生真菌菌株在500至50μgmL -1 的濃度下均具有出色的活性?；?8S和28S的rRNA之間的內(nèi)部轉(zhuǎn)錄間隔區(qū)（ITS）區(qū)域序列（ITS1、5.8S和ITS2）進(jìn)行的分子鑒定將這些菌株鑒定為四個(gè)屬：Sarocladium（LAEE06），F(xiàn)usarium（LAEE13）， Epicoccum（LAEE14）和Khuskia（LAEE21）。有趣的是，其中三個(gè)來自珊瑚物種，其中兩個(gè)來自同一生物，即Diploria strigosa。通過液相色譜-高分辨率質(zhì)譜（LC-HRMS）獲得的代謝譜表明，真菌次生代謝產(chǎn)物和脂肪酸的組合可能是觀察到的活性的原因。 LC-HRMS分析還顯示存在潛在的新的次生代謝產(chǎn)物。據(jù)我們所知，這是海洋內(nèi)生真菌對QS抑制的首次報(bào)道。

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