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Present and Possible Therapies for Age-Related Macular Degeneration

機(jī)譯:與年齡有關(guān)的黃斑變性的當(dāng)前和可能的療法

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摘要

Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly population worldwide and is defined as a chronic, progressive disorder characterized by changes occurring within the macula reflective of the ageing process. At present, the prevalence of AMD is currently rising and is estimated to increase by a third by 2020. Although our understanding of the several components underpinning the pathogenesis of this condition has increased significantly, the treatment options for this condition remain substantially limited. In this review, we outline the existing arsenal of therapies available for AMD and discuss the additional role of further novel therapies currently under investigation for this debilitating disease.
機(jī)譯:與年齡有關(guān)的黃斑變性(AMD)是全世界老年人中最常見(jiàn)的失明原因,被定義為一種慢性進(jìn)行性疾病,其特征是黃斑內(nèi)發(fā)生的變化反映了衰老過(guò)程。目前,AMD的患病率目前正在上升,估計(jì)到2020年將增加三分之一。盡管我們對(duì)支撐這種疾病發(fā)病機(jī)理的幾種成分的了解已大大增加,但該疾病的治療選擇仍然受到很大限制。在這篇綜述中,我們概述了可用于AMD的現(xiàn)有療法庫(kù),并討論了目前正在研究的對(duì)該衰弱性疾病進(jìn)行進(jìn)一步新穎療法的其他作用。

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