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The Role of Lumican in Ocular Disease

機(jī)譯：Lumican在眼病中的作用

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Lumican is keratan sulfate proteoglycan of the small leucine rich proteoglycan family. Through studies in animal models lumican has been found to be critical in maintaining corneal clarity. It maintains ordered collagen fibrils which are vital in keeping the cornea transparent. It may also be important in primary open angle glaucoma influencing aqueous outflow. Lumican deficiency in mice results in increased axial length with fibromodulin deficiency and thinner sclerae. There is evidence suggesting that this characteristic may be pertinent in humans and lumican gene polymorphisms could be related to high myopia. Lumican plays a fundamental role in inflammation and wound healing. It localises macrophages to the site of corneal injury and recruits neutrophils in lipopolysaccharide-induced keratitis in mice. It has also been shown to bind lipopolysaccharide which may be critical in inflammatory diseases such as uveitis. Lumican is also important in wound healing revealing decreased synthesis in scar tissue and mediating Fas-Fas ligand interactions. It is present in human placenta and amniotic membrane suggesting that it may ensure viable amniotic membrane grafts. Lumican may also be involved in the formation of posterior capsular opacification following cataract surgery. Research into the pivotal role of lumican in the pathogenesis of ocular disease has resulted in greater understanding of the key role which proteoglycans play in human disease.
機(jī)譯：Lumican是富含亮氨酸的蛋白聚糖家族中的硫酸角質(zhì)素蛋白聚糖。通過對(duì)動(dòng)物模型的研究，發(fā)現(xiàn)盧米肯在保持角膜透明性方面至關(guān)重要。它保持有序的膠原纖維，這對(duì)于保持角膜透明至關(guān)重要。這在影響房水流出的原發(fā)性開角型青光眼中也可能很重要。小鼠中的Lumican缺乏癥會(huì)導(dǎo)致軸向長(zhǎng)度增加，而纖維調(diào)節(jié)蛋白缺乏癥和鞏膜變薄。有證據(jù)表明，該特征可能與人類有關(guān)，并且lumican基因多態(tài)性可能與高度近視有關(guān)。 Lumican在炎癥和傷口愈合中起著基本作用。它使巨噬細(xì)胞定位于角膜損傷部位，并在脂多糖誘導(dǎo)的小鼠角膜炎中募集中性粒細(xì)胞。還已經(jīng)顯示出它結(jié)合脂多糖，這在諸如葡萄膜炎的炎性疾病中可能是關(guān)鍵的。 Lumican在傷口愈合中也很重要，它揭示了疤痕組織中合成的減少和介導(dǎo)Fas-Fas配體相互作用。它存在于人胎盤和羊膜中，提示它可以確?？尚械难蚰ひ浦参?。在白內(nèi)障手術(shù)后，Lumican也可能參與了后囊混濁的形成。對(duì)Lumican在眼部疾病發(fā)病機(jī)理中的關(guān)鍵作用的研究使人們對(duì)蛋白聚糖在人類疾病中發(fā)揮的關(guān)鍵作用有了更深入的了解。

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