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首頁(yè)> 外文期刊>Molecular Biology and Evolution >mtDNA Variation Predicts Population Size in Humans and Reveals a Major Southern Asian Chapter in Human Prehistory
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mtDNA Variation Predicts Population Size in Humans and Reveals a Major Southern Asian Chapter in Human Prehistory

機(jī)譯：mtDNA變異預(yù)測(cè)人類的種群規(guī)模，并揭示人類史前南亞的主要章節(jié)

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The relative timing and size of regional human population growth following our expansion from Africa remain unknown. Human mitochondrial DNA (mtDNA) diversity carries a legacy of our population history. Given a set of sequences, we can use coalescent theory to estimate past population size through time and draw inferences about human population history. However, recent work has challenged the validity of using mtDNA diversity to infer species population sizes. Here we use Bayesian coalescent inference methods, together with a global data set of 357 human mtDNA coding-region sequences, to infer human population sizes through time across 8 major geographic regions. Our estimates of relative population sizes show remarkable concordance with the contemporary regional distribution of humans across Africa, Eurasia, and the Americas, indicating that mtDNA diversity is a good predictor of population size in humans. Plots of population size through time show slow growth in sub-Saharan Africa beginning 143–193 kya, followed by a rapid expansion into Eurasia after the emergence of the first non-African mtDNA lineages 50–70 kya. Outside Africa, the earliest and fastest growth is inferred in Southern Asia ～52 kya, followed by a succession of growth phases in Northern and Central Asia (～49 kya), Australia (～48 kya), Europe (～42 kya), the Middle East and North Africa (～40 kya), New Guinea (～39 kya), the Americas (～18 kya), and a second expansion in Europe (～10–15 kya). Comparisons of relative regional population sizes through time suggest that between approximately 45 and 20 kya most of humanity lived in Southern Asia. These findings not only support the use of mtDNA data for estimating human population size but also provide a unique picture of human prehistory and demonstrate the importance of Southern Asia to our recent evolutionary past.
機(jī)譯：我們從非洲擴(kuò)展后，區(qū)域人口增長(zhǎng)的相對(duì)時(shí)間和規(guī)模仍然未知。人類線粒體DNA（mtDNA）多樣性承載著我們?nèi)丝跉v史的遺產(chǎn)。給定一組序列，我們可以使用合并理論通過(guò)時(shí)間估算過(guò)去的人口規(guī)模，并得出有關(guān)人類人口歷史的推論。但是，最近的工作挑戰(zhàn)了使用mtDNA多樣性推斷物種種群規(guī)模的有效性。在這里，我們使用貝葉斯合并推斷方法，以及357個(gè)??人類mtDNA編碼區(qū)序列的全球數(shù)據(jù)集，通過(guò)時(shí)間跨8個(gè)主要地理區(qū)域來(lái)推斷人口規(guī)模。我們對(duì)相對(duì)人口規(guī)模的估計(jì)與非洲，歐亞大陸和美洲的當(dāng)代人類區(qū)域分布具有顯著的一致性，這表明mtDNA多樣性是人類人口規(guī)模的良好預(yù)測(cè)指標(biāo)。隨時(shí)間推移的人口規(guī)模圖顯示，撒哈拉以南非洲地區(qū)的增長(zhǎng)緩慢，始于143-193 kya，隨后出現(xiàn)了第一個(gè)非非洲mtDNA譜系50-70 kya，隨后迅速擴(kuò)展到了歐亞大陸。在非洲以外，最早和最快的增長(zhǎng)是在南亞?52 kya，然后是北亞和中亞（?49?? kya），澳大利亞（?48 kya），歐洲（?42 kya），中東和北非（?40 kya），新幾內(nèi)亞（?39 kya），美洲（?18 kya），以及歐洲的第二次擴(kuò)張（?10-15 kya）。通過(guò)時(shí)間對(duì)相對(duì)區(qū)域人口規(guī)模的比較表明，大約45至20 kya的人類大多數(shù)生活在南亞。這些發(fā)現(xiàn)不僅支持使用mtDNA數(shù)據(jù)估算人口規(guī)模，而且還提供了人類史前史的獨(dú)特圖片，并證明了南亞對(duì)我們最近的進(jìn)化歷史的重要性。

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    《Molecular Biology and Evolution》 |2008年第2期|468-474|共7頁(yè)
  • 作者單位

    Institute of Cognitive and Evolutionary Anthropology University of Oxford 58A Banbury Rd Oxford OX2 6QS United Kingdom;

    Psychology Department University of Auckland Auckland New Zealand;

    Bioinformatics Institute and Department of Computer Science University of Auckland Auckland New Zealand;

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