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Geometrical effect characterization of femtosecond-laser manufactured glass microfluidic chips based on optical manipulation of submicroparticles

機(jī)譯:飛秒激光制造的玻璃微流控芯片基于亞微粒的光學(xué)操縱的幾何效應(yīng)表征

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摘要

Microfluidic devices provide a platform with wide ranging applications from environmental monitoring to disease diagnosis. They offer substantive advantages but are often not optimized or designed to be used by nonexpert researchers. Microchannels of a microanalysis platform and their geometrical characterization are of eminent importance when designing such devices. We present a method that is used to optimize each micro-channel within a device using high-throughput particle manipulation. For this purpose, glass-based microfluidic devices, with three-dimensional channel networks of several geometrical sizes, were fabricated by employing laser fabrication techniques. The effect of channel geometry was investigated by employing an optical tweezer. The optical trapping force depends on the flow velocity that is associated with the dimensions of the microchan-nel. We observe a linear dependence of the trapping efficiency and of the fluid flow velocity, with the channel dimensions. We determined that the highest trapping efficiency was achieved for microchannels with aspect ratio equal to one. Numerical simulation validated the impact of the device design dimensions on the trapping efficiency. This investigation indicates that the geometrical characteristics, the flow velocity, and trapping efficiency are crucial and should be considered when fabricating microfluidic devices for cell studies.
機(jī)譯:微流體設(shè)備為從環(huán)境監(jiān)測(cè)到疾病診斷的廣泛應(yīng)用提供了平臺(tái)。它們提供了實(shí)質(zhì)性的優(yōu)勢(shì),但通常沒(méi)有經(jīng)過(guò)優(yōu)化或設(shè)計(jì)以供非專(zhuān)業(yè)研究人員使用。在設(shè)計(jì)此類(lèi)設(shè)備時(shí),微分析平臺(tái)的微通道及其幾何特征非常重要。我們提出了一種使用高通量粒子處理技術(shù)來(lái)優(yōu)化設(shè)備中每個(gè)微通道的方法。為此,通過(guò)采用激光制造技術(shù)來(lái)制造具有幾種幾何尺寸的三維通道網(wǎng)絡(luò)的玻璃基微流體裝置。通過(guò)使用光學(xué)鑷子研究了通道幾何形狀的影響。光學(xué)捕獲力取決于與微通道尺寸相關(guān)的流速。我們觀察到捕集效率和流體流速與通道尺寸之間的線(xiàn)性關(guān)系。我們確定縱橫比等于1的微通道實(shí)現(xiàn)了最高捕獲效率。數(shù)值模擬驗(yàn)證了器件設(shè)計(jì)尺寸對(duì)捕集效率的影響。這項(xiàng)研究表明,幾何特征,流速和捕集效率至關(guān)重要,在制造用于細(xì)胞研究的微流體裝置時(shí)應(yīng)予以考慮。

著錄項(xiàng)

  • 來(lái)源
    《Optical engineering》 |2017年第12期|124111.1-124111.6|共6頁(yè)
  • 作者單位

    National Technical University of Athens, Physics Department, Laboratory of Optoelectronics, Lasers and their Applications, Athens, Greece;

    Heriot-Watt University, Institute of Photonics and Quantum Sciences, School of Engineering and Physical Sciences, Non-Linear Optics Group, Edinburgh, United Kingdom;

    National Technical University of Athens, Physics Department, Laboratory of Optoelectronics, Lasers and their Applications, Athens, Greece;

    Heriot-Watt University, Institute of Photonics and Quantum Sciences, School of Engineering and Physical Sciences, Non-Linear Optics Group, Edinburgh, United Kingdom;

    National Technical University of Athens, Physics Department, Laboratory of Optoelectronics, Lasers and their Applications, Athens, Greece;

    National Technical University of Athens, Physics Department, Laboratory of Optoelectronics, Lasers and their Applications, Athens, Greece;

  • 收錄信息 美國(guó)《科學(xué)引文索引》(SCI);美國(guó)《工程索引》(EI);
  • 原文格式 PDF
  • 正文語(yǔ)種 eng
  • 中圖分類(lèi)
  • 關(guān)鍵詞

    femtosecond laser; microfluidics; optical tweezers; glasses; geometrical characteristics; velocity measurements;

    機(jī)譯:飛秒激光微流體光學(xué)鑷子;眼鏡;幾何特征速度測(cè)量;

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