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首頁> 外軍國防科技報(bào)告 >ARL-TR-8628 - Development of a Computational Framework to Study Ion Transport through Mechanosensitive Ion Channels | U.S. Army Research Laboratory
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ARL-TR-8628 - Development of a Computational Framework to Study Ion Transport through Mechanosensitive Ion Channels | U.S. Army Research Laboratory

機(jī)譯：ARL-TR-8628 - 開發(fā)通過機(jī)械敏感離子通道研究離子遷移的計(jì)算框架美國陸軍研究實(shí)驗(yàn)室

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摘要

External physical forces on neurons can alter cell-membrane tension and activate mechanosensitivity in ion channels, thereby altering membrane electrostatic potential, which may exacerbate traumatic brain injury. We present an efficient computational framework for studying ion channels under user-specified conditions of membrane potential, membrane tension, and asymmetric concentrations of multiple ion species. We demonstrate the use of the framework on a model neuronal K+ ion channel, finding reasonable agreement with experimental results. The methodology is general and can be applied to other ionchannels and membrane proteins with various combinations of membrane potential, membrane tension, and ion concentration gradient.

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  • 作者單位
  • 年(卷),期 2019(),
  • 年度 2019
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  • 總頁數(shù) 25
  • 原文格式 PDF
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  • 中圖分類
  • 網(wǎng)站名稱 美國陸軍研究實(shí)驗(yàn)室
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