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A new diagnostic for cancer dynamics: Status and initial tests of the NANIVID

機(jī)譯：癌癥動(dòng)態(tài)的新診斷：納米的狀態(tài)和初始測(cè)試

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The Tumor MicroEnvironment for Metastasis (TMEM) is a critical determinant which will presage the evolution of primary tumors and the resulting metastatic dynamics. Primary tumor cells up and down regulate certain genes which increase motility and cause a disregard for positional information. We report on the development of a new tool for the documentation of cancer cell migration (initial targets: the rat mammary adenocarcinoma cell lines MTLn3 with an over expression of Mena+++). This tool, the NANo IntraVital Device (NANIVID), is a multi-functional nanosystem composed of a chemoattractant source (hydrogel-EGF), capsule (cell trap), counter (transparent, interdigitated electrode arrays for sensing cell arrival), and remote reporter (readout electronics). The device will be retrieved from the tumor site and the cells will be expelled for subsequent assay. The NANIVID will be used in conjunction with the current catheter-based approach in which a needle is loaded with a chemoattractant source and injected into the tumor. A major drawback in the catheter approach is the short cell collection time and lack of real time registering and reporting of cell arrival. This paper will present the current status of the NANIVID prototypes developed in which a transparent implantable device is loaded with chemoattractant source and placed near candidate mammary gland tumors in an established rat model for multiple days or weeks. This series of experiments will allow the comparison of methods and to benchmark the NANIVID for use in research. Initial results of these experiments and NANIVID design modifications will be presented.
機(jī)譯：用于轉(zhuǎn)移的腫瘤微環(huán)境（TMEM）是一個(gè)關(guān)鍵的決定因素，其將展示原發(fā)性腫瘤的演變和所產(chǎn)生的轉(zhuǎn)移動(dòng)力學(xué)。原發(fā)性腫瘤細(xì)胞上下調(diào)節(jié)某些基因，這些基因增加了運(yùn)動(dòng)性并導(dǎo)致忽略了定位信息。我們報(bào)告了癌細(xì)胞遷移文獻(xiàn)的新工具的開(kāi)發(fā)（初始靶標(biāo)：大鼠乳腺癌細(xì)胞系MTLN3過(guò)度表達(dá)MENA +++）。該工具是納米氈（納米型），是由化學(xué)引導(dǎo)源（水凝膠-EGF），膠囊（細(xì)胞捕集器），計(jì)數(shù)器（用于傳感細(xì)胞到達(dá)的透明，透明的電極陣列）組成的多功能納米系統(tǒng)，以及遙控器（讀數(shù)電子）。將從腫瘤部位檢索該裝置，并且細(xì)胞將被驅(qū)逐用于后續(xù)測(cè)定。納米的將與當(dāng)前的基于導(dǎo)管的方法結(jié)合使用，其中針被加載有培養(yǎng)物源并注入腫瘤。導(dǎo)管方法中的一個(gè)主要缺點(diǎn)是短的電池收集時(shí)間，并且缺乏實(shí)時(shí)登記和報(bào)告細(xì)胞到達(dá)。本文將介紹開(kāi)發(fā)的原型NANIVID其中透明植入裝置裝載有趨化源和放置在靠近候選乳腺腫瘤中多天或數(shù)周的既定大鼠模型的當(dāng)前狀態(tài)。這一系列實(shí)驗(yàn)將允許比較方法和基準(zhǔn)用于研究的納米。將提出這些實(shí)驗(yàn)和納米設(shè)計(jì)修改的初始結(jié)果。

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