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Cellular Obstruction Clearance of Proximal Ventricular Catheters Using Low-voltage Joule Heating

機(jī)譯：低壓焦耳加熱清除近端心室導(dǎo)管的細(xì)胞阻塞

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摘要

Cellular attachment and invasion is the primary source of obstruction in proximal ventricular catheters causing shunt malfunctions for hydrocephalus patients. The standard approach to treat such cases involves surgical intervention which unfortunately is accompanied by inherent risks and a likelihood of future malfunction. We present a methodology for obstruction clearance within a proximal ventricular catheter. Our proposed device contains a pair of luminal electrodes that generate heat by impedance or Joule heating whose volume of action is confined primarily within the lumen of the catheter as well as its ports where cellular build-up normally occurs. We show that the induced local heating can clear a cellular monolayer in a mock proximal ventricular catheter without harming cells located close to the exterior of the catheter. Using a combination of simulation studies and in-vitro benchtop experiments, we demonstrate the feasibility and establish preliminary work towards developing a prototype design of a non-invasive self-clearing ventricular catheter system.
機(jī)譯：細(xì)胞附著和侵襲是近端心室導(dǎo)管阻塞的主要來源，導(dǎo)致腦積水患者的分流失靈。治療此類病例的標(biāo)準(zhǔn)方法包括手術(shù)干預(yù)，但不幸的是伴隨著固有的風(fēng)險(xiǎn)和將來發(fā)生故障的可能性。我們提出了近端心室導(dǎo)管內(nèi)阻塞清除的方法。我們提出的設(shè)備包含一對(duì)通過阻抗或焦耳熱產(chǎn)生熱量的腔電極，其作用體積主要限制在導(dǎo)管的內(nèi)腔以及通常發(fā)生細(xì)胞堆積的端口內(nèi)。我們顯示，誘導(dǎo)的局部加熱可以清除模擬的近端心室導(dǎo)管中的細(xì)胞單層，而不會(huì)損害靠近導(dǎo)管外部的細(xì)胞。使用模擬研究和體外臺(tái)式實(shí)驗(yàn)的結(jié)合，我們證明了可行性，并建立了開發(fā)無創(chuàng)自清除心室導(dǎo)管系統(tǒng)原型設(shè)計(jì)的初步工作。

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  • 作者

    Sane, Abhay V.;

  • 作者單位

    University of Illinois at Chicago.;

  • 授予單位 University of Illinois at Chicago.;
  • 學(xué)科 Biomedical engineering.
  • 學(xué)位 M.S.
  • 年度 2017
  • 頁碼 135 p.
  • 總頁數(shù) 135
  • 原文格式 PDF
  • 正文語種 eng
  • 中圖分類 遙感技術(shù);
  • 關(guān)鍵詞

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