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首頁> 外文期刊>Biomedical Engineering, IEEE Transactions on >Cellular Obstruction Clearance in Proximal Ventricular Catheters Using Low-Voltage Joule Heating
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Cellular Obstruction Clearance in Proximal Ventricular Catheters Using Low-Voltage Joule Heating

機譯：低電壓焦耳加熱對近端心室導管的細胞阻塞清除作用

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Objective: Proximal obstruction due to cellular material is a major cause of shunt failure in hydrocephalus management. The standard approach to treat such cases involves surgical intervention which unfortunately is accompanied by inherent surgical risks and a likelihood of future malfunction. We report a prototype design of a proximal ventricular catheter capable of noninvasively clearing cellular obstruction. Methods: In-vitro cell-culture methods show that low-intensity ac signals successfully destroy a cellular layer in a localized manner by means of Joule heating induced hyperthermia. A detailed electrochemical model for determining the temperature distribution and ionic current density for an implanted ventricular catheter supports our experimental observations. Results: In-vitro experiments with cells cultured in a plate as well as cells seeded in mock ventricular catheters demonstrated that localized heating between 43 °C and 48 °C caused cell death. This temperature range is consistent with hyperthermia. The electrochemical model verified that Joule heating due to ionic motion is the primary contributor to heat generation. Conclusion: Hyperthermia induced by Joule heating can clear cellular material in a localized manner. This approach is feasible to design a noninvasive self-clearing ventricular catheter system. Significance: A shunt system capable of clearing cellular obstruction could significantly reduce the need for future surgical interventions, lower the cost of disease management, and improve the quality of life for patients suffering from hydrocephalus.
機譯：目的：由細胞物質引起的近端阻塞是腦積水管理中分流失敗的主要原因。治療此類病例的標準方法包括外科手術干預，不幸的是，手術干預伴隨著固有的外科手術風險和將來發(fā)生故障的可能性。我們報告能夠無創(chuàng)清除細胞阻塞的近端心室導管的原型設計。方法：體外細胞培養(yǎng)方法表明，低強度的交流信號通過焦耳熱誘導的高溫成功地局部破壞了細胞層。用于確定植入式心室導管的溫度分布和離子電流密度的詳細電化學模型支持我們的實驗觀察。結果：在板上培養(yǎng)的細胞以及在模擬心室導管中接種的細胞的體外實驗表明，在43°C至48°C之間進行局部加熱會導致細胞死亡。該溫度范圍與體溫一致。電化學模型驗證了由于離子運動引起的焦耳熱是產生熱量的主要因素。結論：焦耳熱引起的體溫過高可以局部清除細胞內物質。這種方法對于設計無創(chuàng)自清潔心室導管系統是可行的。意義：能夠清除細胞阻塞的分流系統可以顯著減少對未來外科手術的需求，降低疾病管理的成本，并改善腦積水患者的生活質量。

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