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New insights on the modeling of the molecular mechanisms underlying neural maps alignment in the midbrain

機譯:內(nèi)腦中神經(jīng)圖底層底層底層底層底層機制建模的新見解

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摘要

We previously identified and modeled a principle of visual map alignment in the midbrain involving the mapping of the retinal projections and concurrent transposition of retinal guidance cues into the superior colliculus providing positional information for the organization of cortical V1 projections onto the retinal map (Savier et al., 2017). This principle relies on mechanisms involving Epha/Efna signaling, correlated neuronal activity and axon competition. Here, using the 3-step map alignment computational model, we predict and validate in vivo the visual mapping defects in a well-characterized mouse model. Our results challenge previous hypotheses and provide an alternative, although complementary, explanation for the phenotype observed. In addition, we propose a new quantification method to assess the degree of alignment and organization between maps, allowing inter-model comparisons. This work generalizes the validity and robustness of the 3-step map alignment algorithm as a predictive tool and confirms the basic mechanisms of visual map organization.
機譯:先前,我們在中腦中識別并建模了涉及視網(wǎng)膜投影和視網(wǎng)膜引導(dǎo)線索的映射到高級小集的上腦中的視覺映射對準(zhǔn)原理,以提供將皮質(zhì)V1投影組織的位置信息(Savier等。,2017)。這一原理依賴于涉及Epha / EFNA信號傳導(dǎo),相關(guān)神經(jīng)元活動和軸突競爭的機制。這里,使用3步映射對齊計算模型,我們預(yù)測并驗證在良好表征鼠標(biāo)模型中的視覺映射缺陷中。我們的結(jié)果挑戰(zhàn)以前的假設(shè),并提供替代,盡管互補,對表型觀察到的解釋。此外,我們提出了一種新的量化方法,以評估地圖之間的對齊程度和組織程度,允許模型進行比較。這項工作概括了3步映射對齊算法作為預(yù)測工具的有效性和穩(wěn)健性,并確認了可視地圖組織的基本機制。

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