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首頁> 外文期刊>Experimental and therapeutic medicine >An altered expression of genes involved in the regulation of ion channels in atrial myocytes is correlated with the risk of atrial fibrillation in patients with heart failure
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An altered expression of genes involved in the regulation of ion channels in atrial myocytes is correlated with the risk of atrial fibrillation in patients with heart failure

機(jī)譯：心力衰竭患者心房肌細(xì)胞離子通道調(diào)控相關(guān)基因表達(dá)的改變與房顫風(fēng)險(xiǎn)相關(guān)

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The aim of this study was to investigate the correlation between the altered expression of genes involved in the regulation of ion channels in atrial myocytes and the risk of atrial fibrillation (AF) in patients with heart failure (HF). Right atrial appendages were obtained from 18 HF patients and 18 patients with normal cardiac functions who had undergone surgery. The mRNA expression levels of Kv4.3 alpha, KvLQT1, Kv1.5, L-Ca alpha(1c) and NCX were measured by reverse transcription-PCR (RT-PCR). Protein expression levels were also detected by western blotting. In comparison with the control group exhibiting normal cardiac functions, the mRNA and protein expression levels of Kv4.3 alpha, KvLQT1 and L-Ca alpha(1c), were significantly reduced in HF patients. By contrast, the mRNA and protein expression levels of NCX were significantly increased in HF patients compared with the control group (P<0.01). The mRNA expression levels of Kv1.5 were not evidently altered. We demonstrated that increased levels of Kv4.3 alpha, KvLQT1 and L-Ca alpha(1c) and decreased levels of NCX are correlated with the risk of AF in HF patients. Changes in the gene expression of ion channel-related proteins may therefore be used as biological markers of AF occurring in HF patients in future studies.
機(jī)譯：這項(xiàng)研究的目的是調(diào)查心力衰竭（HF）患者心房肌細(xì)胞離子通道調(diào)控基因的表達(dá)變化與房顫（AF）風(fēng)險(xiǎn)之間的相關(guān)性。從18例HF患者和18例心臟功能正常的接受手術(shù)的患者中獲得右心耳。通過逆轉(zhuǎn)錄PCR（RT-PCR）測(cè)量Kv4.3α，KvLQT1，Kv1.5，L-Caα（1c）和NCX的mRNA表達(dá)水平。蛋白表達(dá)水平也通過蛋白質(zhì)印跡法檢測(cè)。與具有正常心臟功能的對(duì)照組相比，HF患者的Kv4.3 alpha，KvLQT1和L-Ca alpha（1c）的mRNA和蛋白表達(dá)水平顯著降低。相比之下，HF組患者NCX的mRNA和蛋白表達(dá)水平明顯高于對(duì)照組（P <0.01）。 Kv1.5的mRNA表達(dá)水平?jīng)]有明顯改變。我們證明，HF患者中Kv4.3 alpha，KvLQT1和L-Ca alpha（1c）的水平升高以及NCX的水平降低與房顫風(fēng)險(xiǎn)相關(guān)。因此，在未來的研究中，離子通道相關(guān)蛋白的基因表達(dá)變化可以用作發(fā)生在HF患者中的房顫的生物學(xué)標(biāo)志。

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