Preferential induction of G1 arrest in androgen-responsive human prostate cancer cells by androgen receptor signaling antagonists DL3 and antiandrogen bicalutamide.

Tan Z; Wortman M; Lu S; Dong Z

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首頁> 外文期刊>Cancer letters >Preferential induction of G1 arrest in androgen-responsive human prostate cancer cells by androgen receptor signaling antagonists DL3 and antiandrogen bicalutamide.

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Preferential induction of G1 arrest in androgen-responsive human prostate cancer cells by androgen receptor signaling antagonists DL3 and antiandrogen bicalutamide.

機(jī)譯：雄激素受體信號(hào)傳導(dǎo)拮抗劑DL3和抗雄激素比卡魯胺可優(yōu)先誘導(dǎo)雄激素反應(yīng)性人前列腺癌細(xì)胞中G1阻滯。

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The purpose of this study was to further characterize cell growth-inhibitory effects of a recently identified androgen receptor (AR) signaling inhibitor 6-amino-2-[2-(4-tert-butyl-pnenoxy)-ethylsulfanyl]-1H-pyrimidin-4-one (DL3)(5) and antiandrogen bicalutamide (Bic). DL3 was more potent than Bic in induction of G1 arrest and reduction of G1-related cell cycle protein expression in AR-positive LNCaP cells. DL3, but not Bic, moderately inhibited growth of AR-negative PC-3 cells independent of G1 arrest. The data indicated that DL3 inhibit cell growth in both AR-dependent and -independent manners and is potentially a potent therapeutic agent for the management of advanced human prostate cancer.

機(jī)譯：這項(xiàng)研究的目的是進(jìn)一步表征最近確定的雄激素受體（AR）信號(hào)抑制劑6-氨基-2- [2-（4-叔丁基-苯氧基）-乙基硫基] -1H-嘧啶的細(xì)胞生長(zhǎng)抑制作用-4-one（DL3）（5）和抗雄激素比卡魯胺（Bic）。 DL3比Bic在誘導(dǎo)AR陽性LNCaP細(xì)胞中G1停滯和減少G1相關(guān)細(xì)胞周期蛋白表達(dá)方面更有效。 DL3（而非Bic）可適度抑制AR陰性PC-3細(xì)胞的生長(zhǎng)，而與G1阻滯無關(guān)。數(shù)據(jù)表明，DL3以AR依賴性和非依賴性方式抑制細(xì)胞生長(zhǎng)，并且潛在地是用于治療晚期人前列腺癌的有效治療劑。

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《Cancer letters》 |2010年第2期|共8頁
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Tan Z; Wortman M; Lu S; Dong Z;
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正文語種 eng
中圖分類腫瘤學(xué);
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1. Preferential induction of G1 arrest in androgen-responsive human prostate cancer cells by androgen receptor signaling antagonists DL3 and antiandrogen bicalutamide. [J] . Tan Z, Wortman M, Lu S, Cancer letters . 2010,第2期

機(jī)譯：雄激素受體信號(hào)傳導(dǎo)拮抗劑DL3和抗雄激素比卡魯胺可優(yōu)先誘導(dǎo)雄激素反應(yīng)性人前列腺癌細(xì)胞中G1阻滯。
2. Galbanic acid decreases androgen receptor abundance and signaling and induces G1 arrest in prostate cancer cells. [J] . Zhang Y, Kim KH, Zhang W, International Journal of Cancer =: Journal International du Cancer . 2012,第1期

機(jī)譯：高巴酸會(huì)降低雄激素受體的豐度和信號(hào)傳導(dǎo)，并誘導(dǎo)前列腺癌細(xì)胞中的G1阻滯。
3. Activation of p53 signaling and inhibition of androgen receptor mediate tanshinone IIA induced G1 arrest in LNCaP prostate cancer cells [J] . Won S.-H., Lee H.-J., Jeong S.-J., Phytotherapy research: PTR . 2012,第5期

機(jī)譯：p53信號(hào)的激活和雄激素受體的抑制介導(dǎo)丹參酮IIA誘導(dǎo)LNCaP前列腺癌細(xì)胞中的G1阻滯
4. Proteome-wide drug dose-response of prostate cancer cell lines exposed to androgen receptor antagonist by microflow-LC SWATH MS analysis [C] . L.C. Gillet, S. Amon, Y. Uchida, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

機(jī)譯：通過Microflow-LC SWATH MS分析將前列腺癌細(xì)胞拮抗劑暴露于雄激素受體拮抗劑的前列腺癌細(xì)胞響應(yīng)
5. Development of pan-antagonists of mutant androgen receptors associated with antiandrogen resistant prostate cancer. [D] . Pan, Hongmu. 2009

機(jī)譯：與抗雄激素抵抗性前列腺癌有關(guān)的突變雄激素受體泛拮抗劑的發(fā)展。
6. Preferential Induction of G1 Arrest in Androgen Responsive Human Prostate Cancer Cells by Androgen Receptor Signaling Antagonists DL3 and antiandrogen bicalutamide [O] . Shan Lu, Zongqin Tan, Matthew Wortman, -1

機(jī)譯：雄激素受體信號(hào)傳導(dǎo)拮抗劑DL3和抗抗原與丁酰胺雄激素響應(yīng)人前列腺癌細(xì)胞優(yōu)先誘導(dǎo)雄激素響應(yīng)人前列腺癌細(xì)胞
7. Preferential induction of G1 arrest in androgen-responsive human prostate cancer cells by androgen receptor signaling antagonists DL3 and antiandrogen bicalutamide [O] . Shan Lu, Zongqin Tan, Matthew Wortman, 2010

機(jī)譯：雄激素受體信號(hào)傳導(dǎo)拮抗劑DL3和抗抗原酰胺癌細(xì)胞對(duì)雄激素響應(yīng)人前列腺癌細(xì)胞的優(yōu)先誘導(dǎo)G1停滯
8. Molecular Determinants of Prostate Cancer Progression Across Race- Ethnicity. Project A - The Human 5RD5A2 Gene and Prostate Cancer Progression. Project B - Androgen Receptor (AR) Signaling in Prostate Cancer Progression. Project C - Cellular and Molecular Markers of Prostate Cancer Progression Core - Epidemiology Core [R] . Ross, R. R. , Reichardt, J. , Coetzee, G. A. , 2002

機(jī)譯：跨越種族的前列腺癌進(jìn)展的分子決定因素。項(xiàng)目a - 人類5RD5a2基因和前列腺癌進(jìn)展。項(xiàng)目B - 雄激素受體（aR）在前列腺癌進(jìn)展中的信號(hào)傳導(dǎo)。項(xiàng)目C - 前列腺癌進(jìn)展核心的細(xì)胞和分子標(biāo)記 - 流行病學(xué)核心

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Preferential induction of G1 arrest in androgen-responsive human prostate cancer cells by androgen receptor signaling antagonists DL3 and antiandrogen bicalutamide.

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