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首頁> 外文期刊>Neurobiology of learning and memory >D-cycloserine facilitates procedural learning but not declarative learning in healthy humans: a randomized controlled trial of the effect of D-cycloserine and valproic acid on overnight properties in the performance of non-emotional memory tasks.
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D-cycloserine facilitates procedural learning but not declarative learning in healthy humans: a randomized controlled trial of the effect of D-cycloserine and valproic acid on overnight properties in the performance of non-emotional memory tasks.

機譯：D-環(huán)絲氨酸有助于健康人的程序學習，而不是聲明式學習：D-環(huán)絲氨酸和丙戊酸對非情感性記憶任務執(zhí)行過程中過夜特性影響的隨機對照試驗。

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Although D-cycloserine (DCS), a partial agonist of the N-methyl-d-aspartate (NMDA) receptor, and valproic acid (VPA), a histone deacetylase inhibitor, have been investigated for their roles in the facilitation of emotional learning, the effects on non-emotional declarative and procedural learning have not been clarified. We performed a randomized, blind, placebo-controlled, 4-arm clinical trial to determine the effects of DCS and VPA on the overnight properties of declarative and procedural learning in 60 healthy adults. Subjects were orally administrated a placebo, 100 mg DCS, 400 mg VPA, or a combination of 100 mg DCS and 400 mg VPA before they performed declarative and procedural learning tasks. Subjects then had their performance retested the following day. We observed that DCS facilitated procedural but not declarative learning and that VPA did not contribute to learning. Surprisingly, however, VPA attenuated the enhancement effect of DCS when coadministered with it. These results suggest that DCS acts as an enhancer of hippocampus-independent learning and that VPA may have an extinguishing pharmacological effect on excitatory post-synaptic action potentials that NMDA receptors regulate within procedural learning.
機譯：盡管已研究了N-甲基-d-天冬氨酸（NMDA）受體的部分激動劑D-環(huán)絲氨酸（DCS）和組蛋白脫乙酰基酶抑制劑丙戊酸（VPA）在促進情緒學習中的作用，對非情感性陳述式和程序性學習的影響尚不清楚。我們進行了一項隨機，盲目，安慰劑對照的4臂臨床試驗，以確定DCS和VPA對60名健康成年人的宣告性和程序性學習的過夜特性的影響。在執(zhí)行陳述性和程序性學習任務之前，對受試者口服安慰劑，100 mg DCS，400 mg VPA或100 mg DCS和400 mg VPA的組合。然后在第二天對受試者的表現(xiàn)進行了重新測試。我們觀察到DCS促進了程序學習而非聲明性學習，并且VPA并沒有促進學習。然而，令人驚訝的是，當與VPA并用時，VPA減弱了DCS的增強作用。這些結果表明，DCS可作為海馬獨立學習的增強劑，并且VPA可能對程序性學習中NMDA受體調節(jié)的興奮性突觸后動作電位具有藥理作用。

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