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首頁> 外文期刊>Langenbeck's archives of surgery >Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. A new fracture-healing model at the tibia in rat.
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Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. A new fracture-healing model at the tibia in rat.

機譯：在骨質(zhì)疏松癥的早期階段，雌激素和雷洛昔芬可改善干phy端骨折的愈合。一種新的大鼠脛骨骨折愈合模型。

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BACKGROUND: Fracture healing in osteoporosis is delayed. Quality and speed of fracture healing in osteoporotic fractures are crucial with regard to the outcome of patients. The question arises whether established antiosteoporotic drugs can further improve fracture healing. MATERIALS AND METHODS: Osteoporosis manifests predominantly in the metaphyseal bone. Nevertheless, an established metaphyseal fracture model is lacking. A standardized metaphyseal fracture-healing model with stable plate fixation was developed for rat tibiae. The healing process was analyzed by biomechanical, gene expression, and histomorphometric methods in ovariectomized (OVX) and sham-operated rats (SHAM), compared to standardized estrogen (E)- and raloxifene (R)-supplemented diets. RESULTS: Estrogen and raloxifene improved the biomechanical properties of bone healing compared to OVX (Yield load: SHAM = 63.1 +/- 20.8N, E = 60.8 +/- 17.9N, R = 44.7+/-17.5N, OVX = 32:5 +/- 22.0N). Estrogen vs OVX was significant based on a denser trabecular network. Raloxifene greatly induced total callus formation ((R = 5.3 +/- 0.9 mm2, E = 4.7 +/- 0.5 mm2, SHAM = 4.51 +/- 0.61 mm2, OVX =4.1 +/- 0.6 mm2), whereas estrogen mainly enhanced new endosteal bone formation. There was no correlation between the gene expression (osteocalcin, collagen1alpha1, IGF-1, tartrate-resistant phosphatase) in the callus and the morphology and quality of callus formation. CONCLUSION: Raloxifene and estrogen improve fracture healing in osteoporotic bone significantly with regard to callus formation, resistance, and elasticity. The biomechanically stable metaphyseal osteotomy model with T-plate fixation presented here has proven to be appropriate to investigate fracture healing in osteoporosis.
機譯：背景：骨質(zhì)疏松癥的骨折愈合延遲。骨質(zhì)疏松性骨折的骨折愈合質(zhì)量和速度對于患者的預后至關重要。出現(xiàn)的問題是，既定的抗骨質(zhì)疏松藥物能否進一步改善骨折愈合。材料與方法：骨質(zhì)疏松癥主要表現(xiàn)在干phy端骨中。然而，缺乏建立的干phy端骨折模型。針對大鼠脛骨，建立了具有穩(wěn)定鋼板固定功能的標準化干phy端骨折愈合模型。通過生物力學，基因表達和組織形態(tài)計量學方法分析了卵巢切除（OVX）和假手術(shù)大鼠（SHAM）與標準雌激素（E）和雷洛昔芬（R）補充飲食相比的愈合過程。結(jié)果：與OVX相比，雌激素和雷洛昔芬改善了骨愈合的生物力學特性（載重：SHAM = 63.1 +/- 20.8N，E = 60.8 +/- 17.9N，R = 44.7 +/- 17.5N，OVX = 32： 5 +/- 22.0N）。基于更密集的小梁網(wǎng)絡，雌激素與OVX顯著相關。雷洛昔芬極大地誘導了總愈傷組織的形成（（R = 5.3 +/- 0.9 mm2，E = 4.7 +/- 0.5 mm2，SHAM = 4.51 +/- 0.61 mm2，OVX = 4.1 +/- 0.6 mm2），而雌激素主要增強了新的結(jié)論：雷洛昔芬和雌激素可顯著改善骨質(zhì)疏松性骨的骨折愈合，但骨the中骨鈣蛋白，膠原1alpha1，IGF-1，酒石酸鹽抗性磷酸酶的基因表達與骨us形成的形態(tài)和質(zhì)量之間無相關性。在骨call形成，抵抗力和彈性方面，這里提出的具有T板固定的生物力學穩(wěn)定的干phy端截骨術(shù)模型已被證明適合研究骨質(zhì)疏松癥的骨折愈合。

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