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首頁> 外文OA文獻 >Quinine-catalyzed asymmetric domino Michael-cyclization reaction for the synthesis of spirocyclic oxindoles bearing two spiro quaternary centers and three consecutive stereocenters.

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Quinine-catalyzed asymmetric domino Michael-cyclization reaction for the synthesis of spirocyclic oxindoles bearing two spiro quaternary centers and three consecutive stereocenters.

機譯：奎寧催化的不對稱多米諾骨牌邁克爾環(huán)化反應，用于合成帶有兩個螺四價中心和三個連續(xù)立體中心的螺環(huán)羥吲哚。

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An efficient organocatalytic diastereo- and enantioselective method for the construction of spirocyclic oxindole derivatives bearing two Spiro quaternary centers and three consecutive stereocenters via a domino Michael/cyclization process has been developed. Using commercially available quinine as catalyst, the reactions of 3-isothiocyanato oxindoles with unsaturated pyrazolones and unsaturated isoxazolones proceeded smoothly under mild reaction conditions for giving two classes of spirocyclic oxindole compounds in high to excellent yields with moderate to good diastereoselectivities and enantioselectivities. A plausible dual activation working model was tentatively proposed to account for the stereochemistry of the domino Michael/cyclization process. (C) 2014 Published by Elsevier Ltd.

機譯：已經開發(fā)出一種有效的有機催化非對映和對映選擇性的方法，用于通過多米諾米歇爾/環(huán)化過程構建帶有兩個Spiro季中心和三個連續(xù)的立體中心的螺環(huán)羥吲哚衍生物。使用市售的奎寧作為催化劑，3-異硫氰酸根合吲哚類化合物與不飽和吡唑啉酮和不飽和異惡唑酮的反應在溫和的反應條件下順利進行，從而以中等至良好的非對映選擇性和對映選擇性高收率地獲得了兩類螺環(huán)惡吲哚化合物。暫時提出了一個可行的雙重激活工作模型來解釋多米諾米歇爾/環(huán)化過程的立體化學。（C）2014由Elsevier Ltd.出版

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Cui Bao-Dong; Li Shi-Wu; Zuo Jian; Wu Zhi-Jun; Zhang Xiao-Mei; Yuan Wei-Cheng;
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年度 2014
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1. Quinine-catalyzed asymmetric domino Michael-cyclization reaction for the synthesis of spirocyclic oxindoles bearing two spiro quaternary centers and three consecutive stereocenters [J] . Bao-Dong Cui, Shi-Wu Li, Jian Zuo, Tetrahedron . 2014,第10期

機譯：奎寧催化的不對稱多米諾骨牌邁克爾環(huán)化反應合成帶有兩個螺四價中心和三個連續(xù)立體中心的螺環(huán)羥吲哚
2. Quinine-catalyzed asymmetric domino Michael-cyclization reaction for the synthesis of spirocyclic oxindoles bearing two spiro quaternary centers and three consecutive stereocenters [J] . Bao-Dong Cui, Shi-Wu Li, Jian Zuo, Tetrahedron . 2014,第10期

機譯：奎寧催化的不對稱多米諾骨牌邁克爾環(huán)化反應合成帶有兩個螺四價中心和三個連續(xù)立體中心的螺環(huán)羥吲哚
3. Quinine-catalyzed asymmetric domino Mannich-cyclization reactions of 3-isothiocyanato oxindoles with imines for the synthesis of spirocyclic oxindoles [J] . Bai Mei, Cui Bao-Dong, Zuo Jian, Tetrahedron . 2015,第6期

機譯：奎寧催化的3-異硫氰酸根合吲哚與亞胺的不對稱多米諾骨牌曼尼希環(huán)化反應合成螺環(huán)型羥吲哚
4. Applications of Novel Chiral Spiro Ligands Bearing Isoxazoline/Isoxazole Rings in Palladium-catalyzed Asymmetric Reactions [C] . Gan B. Bairacharva, Priti Koranne, Hiroaki Sasai Symposium on Organometallic Chemistry . 2006

機譯：新型手性肺配體患有異惡唑啉/異惡唑在鈀催化的不對稱反應中的應用
5. I. Studies on the organocatalytic formation of quaternary stereocenters. ii. Studies on the claisen rearrangement as a route to quaternary stereocenters. iii. Asymmetric synthesis of aldehydes bearing quaternary carbon centers via the decarboxylative asymmetric allylic alkylation. [D] . Alberch, Eduardo. 2013

機譯：I.季銨立體中心的有機催化形成研究。 ii。關于克萊森重排作為四元立體中心路徑的研究。 iii。通過脫羧不對稱烯丙基烷基化反應不對稱合成帶有季碳中心的醛。
6. Asymmetric Synthesis of Spirocyclopentane OxindolesContaining Four Consecutive Stereocenters and Quaternary α-NitroEsters via Organocatalytic Enantioselective Michael–MichaelCascade Reactions [O] . PrakashD. Chaudhari, Bor-Cherng Hong, *, 2019

機譯：螺環(huán)戊烷氧化吲哚的不對稱合成包含四個連續(xù)的立體中心和第四級α-硝基通過有機催化對映選擇性邁克爾-邁克爾酯級聯(lián)反應
7. Quinine-catalyzed asymmetric domino Michael-cyclization reaction for the synthesis of spirocyclic oxindoles bearing two spiro quaternary centers and three consecutive stereocenters. [O] . Cui Bao-Dong, Li Shi-Wu, Zuo Jian, 2014

機譯：奎寧催化的不對稱多米諾骨牌邁克爾環(huán)化反應，用于合成帶有兩個螺四價中心和三個連續(xù)立體中心的螺環(huán)羥吲哚。

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Quinine-catalyzed asymmetric domino Michael-cyclization reaction for the synthesis of spirocyclic oxindoles bearing two spiro quaternary centers and three consecutive stereocenters.

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