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A new diagnostic for cancer dynamics: Status and initial tests of the NANIVID

機(jī)譯：一種新的癌癥動(dòng)力學(xué)診斷方法：NANIVID的狀態(tài)和初始測試

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The Tumor MicroEnvironment for Metastasis (TMEM) is a critical determinant which will presage the evolution of primary tumors and the resulting metastatic dynamics. Primary tumor cells up and down regulate certain genes which increase motility and cause a disregard for positional information. We report on the development of a new tool for the documentation of cancer cell migration (initial targets: the rat mammary adenocarcinoma cell lines MTLn3 with an over expression of Mena+++). This tool, the NANo IntraVital Device (NANIVID), is a multi-functional nanosystem composed of a chemoattractant source (hydrogel-EGF), capsule (cell trap), counter (transparent, interdigitated electrode arrays for sensing cell arrival), and remote reporter (readout electronics). The device will be retrieved from the tumor site and the cells will be expelled for subsequent assay. The NANIVID will be used in conjunction with the current catheter-based approach in which a needle is loaded with a chemoattractant source and injected into the tumor. A major drawback in the catheter approach is the short cell collection time and lack of real time registering and reporting of cell arrival. This paper will present the current status of the NANIVID prototypes developed in which a transparent implantable device is loaded with chemoattractant source and placed near candidate mammary gland tumors in an established rat model for multiple days or weeks. This series of experiments will allow the comparison of methods and to benchmark the NANIVID for use in research. Initial results of these experiments and NANIVID design modifications will be presented.
機(jī)譯：腫瘤轉(zhuǎn)移微環(huán)境（TMEM）是決定性的決定因素，它將預(yù)示原發(fā)性腫瘤的發(fā)展以及由此產(chǎn)生的轉(zhuǎn)移動(dòng)力學(xué)。原發(fā)性腫瘤細(xì)胞上下調(diào)節(jié)某些基因，這些基因會(huì)增加運(yùn)動(dòng)性并導(dǎo)致無視位置信息。我們報(bào)告了一種新工具的開發(fā)，該工具可用于記錄癌細(xì)胞的遷移（初始目標(biāo)：Mena +++過表達(dá)的大鼠乳腺腺癌細(xì)胞系MTLn3）。該工具是NANo體內(nèi)器械（NANIVID），是一個(gè)多功能的納米系統(tǒng)，由趨化因子來源（水凝膠-EGF），膠囊（細(xì)胞捕獲器），計(jì)數(shù)器（用于感測細(xì)胞到達(dá)的透明，交叉指狀電極陣列）和遠(yuǎn)程報(bào)告器組成（讀出電子設(shè)備）。從腫瘤部位取回該裝置，并將細(xì)胞排出以進(jìn)行后續(xù)測定。 NANIVID將與當(dāng)前的基于導(dǎo)管的方法結(jié)合使用，在該方法中，將針頭加載趨化因子源并注射到腫瘤中。導(dǎo)管方法的主要缺點(diǎn)是細(xì)胞收集時(shí)間短，缺乏實(shí)時(shí)記錄和報(bào)告細(xì)胞到達(dá)情況。本文將介紹NANIVID原型的當(dāng)前狀態(tài)，在該模型中，透明植入式設(shè)備裝有趨化因子源，并在已建立的大鼠模型中放置在候選乳腺腫瘤附近數(shù)天或數(shù)周。這一系列的實(shí)驗(yàn)將使方法的比較和基準(zhǔn)NANIVID用于研究。將介紹這些實(shí)驗(yàn)和NANIVID設(shè)計(jì)修改的初步結(jié)果。

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