摘要： BACKGROUND Spinal dural arteriovenous fistula(SDAVF)is an extremely rare vascular malformation of the central nervous system that is often confused with degenerative spinal disorders due to similar early symptoms and clinical features.Here,we report a case of SDAVF recurrence 8 years after lumbar spine surgery and summarize relevant literature.CASE SUMMARY A 54-year-old male was admitted to our hospital complaining of lower back pain,numbness in both lower extremities and intermittent claudication.Subsequent imaging identified lumbar spinal stenosis.Following surgical treatment,the patient’s symptoms significantly resolved,and he was able to perform daily activities.However,similar symptoms appeared 8 years later,followed by confirmation of SDAVF diagnosis.The patient underwent neurosurgery 7 mo after symptom onset.The follow-up period lasted 14 mo,and the patient remains with marginal neurological symptoms.CONCLUSION This case highlights the importance of prompt SDAVF diagnosis.Due to its nonspecific clinical presentation,the clinical experience of the surgeon and definitive imaging examination are indispensable.Additionally,timely neurosurgery is effective and may significantly improve patient outcomes.

摘要： Dear editor,Impossible differential cryptanalysis and zero-correlation linear cryptanalysis are two powerful methods in the block cipher field.Herein,we present an automatic tool to find impossible differentials(IDs)and zero-correlation linear approximations(ZCLAs)for both ARX and S-box-based ciphers.Similar to the idea of using mixed-integer linear programming(MILP)models for differential cryptanalysis in[1],we first use linear inequalities to describe all the target cipher''s components exactly.

摘要： The study revealed similarities in attitudes towards freedom,responsibility,and society by comparing the responses of 47 undergraduate students from Kyrgyzstan and 47 undergraduate students from the United States using the method of semantic differential(Kagan,1991;Osgood,Tannenbaum,&Suci,1957/1975)and the original Concept Questionnaire.The results of the study emphasize the universality of the values of freedom and responsibility,and the attitude towards society indicates the adaptive strain characteristic of late adolescence period.

摘要： Systemic lupus erythematosus(SLE)is a systemic autoimmune disease characterized by abnormal cellular and humoral immune responses and excessive autoantibody production.The precise pathologic mechanism of SLE remains elusive.The advent of single-cell RNA sequencing(scRNA-seq)enables unbiased analysis of the molecular differences of cell populations at the single-cell level.We used scRNA-seq to profile the transcriptomes of peripheral blood mononuclear cells from an SLE patient compared with a healthy control(HC).A total of 16,021 cells were analyzed and partitioned into 12 distinct clusters.The marker genes of each cluster and the four major immune cell types(B cells,CD4+T cells,CD8+T cells,myeloid cells,and NK cells)were determined.Moreover,several genes involved in antigen processing and presentation through MHCII were highly enriched.GO enrichment analyses revealed abnormal gene expression patterns and signaling pathways in SLE.Of note,pseudotime analysis revealed that there was a different lineage hierarchy in the peripheral blood mononuclear cells(PBMCs)of the SLE patient,indicating that the cell states were substantially altered under disease conditions.Our analysis provides a comprehensive map of the cell types and states of the PBMCs of SLE patients at the single-cell level for a better understanding of the pathogenesis,diagnosis,and treatment of SLE.

摘要： Myelodysplastic syndromes(MDS)are highly heterogeneous myeloid neoplasms,and a large number of patients are difficult to diagnose and classify by blood and bone marrow examination.As a surface marker of granulocyte,studies have shown CD10 can be used to define the degree of granulocyte maturation in MDS patients.However,whether it can be used for differential diagnosis of MDS and other hematological diseases remains inconclusive.To explore the value of CD10 for differential diagnosis of MDS,60 newly diagnosed MDS,20 aplastic anemia(AA)patients,and 35 iron-deficient anemia(IDA)patients were selected for this study.Bone marrow(BM)specimens were processed for surface marker analysis and labeled with pre-conjugated monoclonal antibodies.Stained cells were detected by flow cytometry.Our results indicated that CD10-positive granulocytes were significantly decreased in BM of MDS patients than AA and IDA patients,and the level of CD10-positive mature granulocytes was not associated with the clinical stages of malignancy.Receiver operating characteristic(ROC)areas under the curve(AUC)of CD10-positive granulocytes was 0.86 and 0.85,respectively,in MDS patients than the IDA group and AA group with good specificity and sensitivity.Further,CD10-positive granulocytes were increased after effective treatment.In conclusion,we found the decrease in CD10-positive granulocytes has a differential diagnostic value of MDS.

摘要： BACKGROUND For periampullary adenocarcinoma,the histological subtype is a better prognostic predictor than the site of tumor origin.Intestinal-type periampullary adenocarcinoma(IPAC)is reported to have a better prognosis than the pancreatobiliary-type periampullary adenocarcinoma(PPAC).However,the classification of histological subtypes is difficult to determine before surgery.Apparent diffusion coefficient(ADC)histogram analysis is a noninvasive,nonenhanced method with high reproducibility that could help differentiate the two subtypes.AIM To investigate whether volumetric ADC histogram analysis is helpful for distinguishing IPAC from PPAC.METHODS Between January 2015 and October 2018,476 consecutive patients who were suspected of having a periampullary tumor and underwent magnetic resonance imaging(MRI)were reviewed in this retrospective study.Only patients who underwent MRI at 3.0 T with different diffusion-weighted images(b-values=800 and 1000 s/mm^2)and who were confirmed with a periampullary adenocarcinoma were further analyzed.Then,the mean,5th,10th,25th,50th,75th,90th,and 95th percentiles of ADC values and ADCmin,ADCmax,kurtosis,skewness,and entropy were obtained from the volumetric histogram analysis.Comparisons were made by an independent Student's t-test or Mann-Whitney U test.Multiple-class receiver operating characteristic curve analysis was performed to determine and compare the diagnostic value of each significant parameter.RESULTS In total,40 patients with histopathologically confirmed IPAC(n=17)or PPAC(n=23)were enrolled.The mean,5th,25th,50th,75th,90th,and 95th percentiles and ADCmax derived from ADC1000 were significantly lower in the PPAC group than in the IPAC group(P<0.05).However,values derived from ADC800 showed no significant difference between the two groups.The 75th percentile of ADC1000 values achieved the highest area under the curve(AUC)for differentiating IPAC from PPAC(AUC=0.781;sensitivity,91%;specificity,59%;cut-off value,1.50×10^-3 mm^2/s).CONCLUSION Volumetric ADC histogram analysis at a b-value of 1000 s/mm2 might be helpful for differentiating the histological subtypes of periampullary adenocarcinoma before surgery.

摘要： A single scan has been performed in Differential Scanning Calorimetry (DSC) at a heating rate of 15oC/min under non-isothermal conditions to investigate the crystallization kinetics of glassy Se90Sb10-xAgx alloys (where x = 2, 4, 6, 8). For this purpose, Handerson’s theory based on non-isothermal method for thermal analysis of single-scan DSC data has been used. The activation energy of crystallization and order parameter has been determined and composition dependence of these parameters has been discussed.

摘要： The goal of the present paper is to investigate an abstract system, called fractional differential variational inequality, which consists of a mixed variational inequality combined with a fractional evolution equation in the framework of Banach spaces. Using discrete approximation approach, an existence theorem of solutions for the inequality is established under some suitable assumptions.

摘要： The paper searched for raw data about wild-caught fish, where a sigmoidal growth function described the mass growth significantly better than non-sigmoidal functions. Specifically, von Bertalanffy’s sigmoidal growth function (metabolic exponent-pair a = 2/3, b = 1) was compared with unbounded linear growth and with bounded exponential growth using the Akaike information criterion. Thereby the maximum likelihood fits were compared, assuming a lognormal distribution of mass (i.e. a higher variance for heavier animals). Starting from 70+ size-at-age data, the paper focused on 15 data coming from large datasets. Of them, six data with 400 - 20,000 data-points were suitable for sigmoidal growth modeling. For these, a custom-made optimization tool identified the best fitting growth function from the general von Bertalanffy-Pütter class of models. This class generalizes the well-known models of Verhulst (logistic growth), Gompertz and von Bertalanffy. Whereas the best-fitting models varied widely, their exponent-pairs displayed a remarkable pattern, as their difference was close to 1/3 (example: von Bertalanffy exponent-pair). This defined a new class of models, for which the paper provided a biological motivation that relates growth to food consumption.

摘要： The first purpose of this striking but difficult paper is to revisit the mathematical foundations of Elasticity (EL) and Electromagnetism (EM) by comparing the structure of these two theories and examining with details their known couplings, in particular piezoelectricity and photoelasticity. Despite the strange Helmholtz and Mach-Lippmann analogies existing between them, no classical technique may provide a common setting. However, unexpected arguments discovered independently by the brothers E. and F. Cosserat in 1909 for EL and by H. Weyl in 1918 for EM are leading to construct a new differential sequence called Spencer sequence in the framework of the formal theory of Lie pseudo groups and to introduce it for the conformal group of space-time with 15 parameters. Then, all the previous explicit couplings can be deduced abstractly and one must just go to a laboratory in order to know about the coupling constants on which they are depending, like in the Hooke or Minkowski constitutive relations existing respectively and separately in EL or EM. We finally provide a new combined experimental and theoretical proof of the fact that any 1-form with value in the second order jets (elations) of the conformal group of space-time can be uniquely decomposed into the direct sum of the Ricci tensor and the electromagnetic field. This result questions the mathematical foundations of both General Relativity (GR) and Gauge Theory (GT). In particular, the Einstein operator (6 terms) must be thus replaced by the adjoint of the Ricci operator (4 terms only) in the study of gravitational waves.

摘要： 基于Compact Differential Evolution算法的光刻機(jī)掩模臺(tái)微動(dòng)臺(tái)的機(jī)械參數(shù)軟測(cè)量方法，屬于半導(dǎo)體制造裝備技術(shù)領(lǐng)域及機(jī)械參數(shù)測(cè)量領(lǐng)域。為了解決現(xiàn)有工件臺(tái)微動(dòng)部分機(jī)械參數(shù)估計(jì)算法精度差的問題。所述方法包括如下步驟：步驟一：根據(jù)掩模臺(tái)微動(dòng)臺(tái)的機(jī)械機(jī)構(gòu)及其理論設(shè)計(jì)，建立微動(dòng)臺(tái)的理想運(yùn)動(dòng)學(xué)模型，確定待測(cè)機(jī)械參數(shù)，建立掩模臺(tái)微動(dòng)臺(tái)含差模型；步驟二：給定位置輸入，驅(qū)動(dòng)微動(dòng)臺(tái)運(yùn)動(dòng)產(chǎn)生位移，將實(shí)際輸出位移與通過(guò)建立的掩模臺(tái)微動(dòng)臺(tái)含差模型計(jì)算出的輸出位移值做差，作為導(dǎo)優(yōu)的目標(biāo)函數(shù)；步驟三：根據(jù)目標(biāo)函數(shù)，利用Compact Differential Evolution優(yōu)化學(xué)習(xí)算法確定待辨識(shí)的機(jī)械參數(shù)。它用于微動(dòng)臺(tái)的機(jī)械參數(shù)求取。

摘要： 基于Compact？Differential？Evolution算法的光刻機(jī)掩模臺(tái)微動(dòng)臺(tái)的機(jī)械參數(shù)軟測(cè)量方法，屬于半導(dǎo)體制造裝備技術(shù)領(lǐng)域及機(jī)械參數(shù)測(cè)量領(lǐng)域。為了解決現(xiàn)有工件臺(tái)微動(dòng)部分機(jī)械參數(shù)估計(jì)算法精度差的問題。所述方法包括如下步驟：步驟一：根據(jù)掩模臺(tái)微動(dòng)臺(tái)的機(jī)械機(jī)構(gòu)及其理論設(shè)計(jì)，建立微動(dòng)臺(tái)的理想運(yùn)動(dòng)學(xué)模型，確定待測(cè)機(jī)械參數(shù)，建立掩模臺(tái)微動(dòng)臺(tái)含差模型；步驟二：給定位置輸入，驅(qū)動(dòng)微動(dòng)臺(tái)運(yùn)動(dòng)產(chǎn)生位移，將實(shí)際輸出位移與通過(guò)建立的掩模臺(tái)微動(dòng)臺(tái)含差模型計(jì)算出的輸出位移值做差，作為導(dǎo)優(yōu)的目標(biāo)函數(shù)；步驟三：根據(jù)目標(biāo)函數(shù)，利用Compact？Differential？Evolution優(yōu)化學(xué)習(xí)算法確定待辨識(shí)的機(jī)械參數(shù)。它用于微動(dòng)臺(tái)的機(jī)械參數(shù)求取。